EP 3133394 B1 20220601 - METHOD FOR MEASURING TOXICITY OF HUMAN CSF
Title (en)
METHOD FOR MEASURING TOXICITY OF HUMAN CSF
Title (de)
VERFAHREN ZUR MESSUNG DER TOXIZITÄT VON HUMANEM CSF
Title (fr)
PROCÉDÉ PERMETTANT DE MESURER LA TOXICITÉ DU LCS HUMAIN
Publication
Application
Priority
- US 201461980206 P 20140416
- JP 2015061765 W 20150416
Abstract (en)
[origin: EP3133394A1] The problem is to provide a method that can quickly and efficiently evaluate the toxicity of human cerebrospinal fluid (CSF) with small amounts of human CSF. The problem is solved by a method comprising administering human CSF into the cerebral ventricle of a rodent such as a mouse, and evaluating the cognitive function of the rodent by using a behavioral pharmacological technique.
IPC 8 full level
G01N 33/48 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP US)
A61B 5/4088 (2013.01 - US); A61K 49/0008 (2013.01 - US); C07K 16/18 (2013.01 - US); G01N 33/5088 (2013.01 - EP US); G01N 33/6896 (2013.01 - EP US); A61B 2010/0077 (2013.01 - EP US); A61B 2503/40 (2013.01 - US); A61B 2503/42 (2013.01 - US); A61K 2039/505 (2013.01 - US); C07K 2317/24 (2013.01 - US); C07K 2317/56 (2013.01 - US); C07K 2317/565 (2013.01 - US); G01N 2500/10 (2013.01 - EP US)
Citation (examination)
KARA A. KITTELBERGER ET AL: "Natural Amyloid-Beta Oligomers Acutely Impair the Formation of a Contextual Fear Memory in Mice", PLOS ONE, vol. 7, no. 1, 4 January 2012 (2012-01-04), pages e29940, XP055231490, DOI: 10.1371/journal.pone.0029940
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 3133394 A1 20170222; EP 3133394 A4 20170913; EP 3133394 B1 20220601; ES 2921180 T3 20220819; JP 6683602 B2 20200422; JP WO2015159963 A1 20170413; US 10232056 B2 20190319; US 2017043039 A1 20170216; WO 2015159963 A1 20151022
DOCDB simple family (application)
EP 15779412 A 20150416; ES 15779412 T 20150416; JP 2015061765 W 20150416; JP 2016513836 A 20150416; US 201515304292 A 20150416