Global Patent Index - EP 3134093 A4

EP 3134093 A4 20171220 - ANALOGS OF N-ACETYLGLUCOSAMINE AND USES THEREOF

Title (en)

ANALOGS OF N-ACETYLGLUCOSAMINE AND USES THEREOF

Title (de)

ANALOGA VON N-ACETYLGLUCOSAMIN UND VERWENDUNGEN DAVON

Title (fr)

ANALOGUES DE LA N-ACÉTYLGLUCOSAMINE ET LEURS UTILISATIONS

Publication

EP 3134093 A4 20171220 (EN)

Application

EP 15783308 A 20150423

Priority

  • US 201461983182 P 20140423
  • US 2015027325 W 20150423

Abstract (en)

[origin: US2017042919A1] The present invention includes a novel method of treating or preventing a disease or disorder associated with low levels of branched N-glycans in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In one embodiment, the subject is further administered at least one additional therapeutic agent.

IPC 8 full level

A61K 31/7008 (2006.01); A61K 31/726 (2006.01); A61P 19/02 (2006.01); A61P 25/00 (2006.01)

CPC (source: EP US)

A23L 33/10 (2016.07 - EP US); A61K 31/7008 (2013.01 - EP US); A61K 31/726 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 19/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); Y02A 50/30 (2017.12 - EP)

Citation (search report)

  • [XYI] KAZUO AZUMA ET AL: "Suppressive Effects of-Acetyl--Glucosamine on Rheumatoid Arthritis Mouse Models", INFLAMMATION, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 35, no. 4, 21 March 2012 (2012-03-21), pages 1462 - 1465, XP035085677, ISSN: 1573-2576, DOI: 10.1007/S10753-012-9459-0
  • [XY] GRIGORIAN A ET AL: "N-acetylglucosamine inhibits T-helper 1 (Th1)/T-helper 17 (Th17) cell responses and treats experimental autoimmune encephalomyelitis", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, BETHESDA, MD, USA, vol. 286, no. 46, 18 November 2011 (2011-11-18), pages 40133 - 40141, XP002711049, ISSN: 1083-351X, [retrieved on 20110929], DOI: 10.1074/JBC.M111.277814
  • [XY] LEE SUNG-UK ET AL: "N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 282, no. 46, 16 November 2007 (2007-11-16), pages 33725 - 33734, XP002567287, ISSN: 0021-9258, [retrieved on 20070913], DOI: 10.1074/JBC.M704839200
  • [X] SALVATORE S ET AL: "A PILOT STUDY OF N-ACETYL GLUCOSAMINE, A NUTRITIONAL SUBSTRATE FOR GLYCOSAMINOGLYCAN SYNTHESIS, IN PAEDIATRIC CHRONIC INFLAMMATORY BOWEL DISEASE", ALIMENTARY PHARMACOLOGY & THERAPEUTICS, BLACKWELL SCIENTIFIC PUBLICATIONS LTD., CAMBRIDGE, GB, vol. 14, no. 12, 1 December 2000 (2000-12-01), pages 1567 - 1579, XP001100038, ISSN: 0269-2813, DOI: 10.1046/J.1365-2036.2000.00883.X
  • [A] H.-L. CHEN ET AL: "T Cell Receptor Signaling Co-regulates Multiple Golgi Genes to Enhance N-Glycan Branching", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 47, 20 November 2009 (2009-11-20), pages 32454 - 32461, XP055071301, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.023630
  • [A] GISELA M VAITAITIS ET AL: "CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 47, no. 14, 24 May 2010 (2010-05-24), pages 2303 - 2313, XP028166192, ISSN: 0161-5890, [retrieved on 20100528], DOI: 10.1016/J.MOLIMM.2010.05.288
  • See references of WO 2015164622A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2015164622 A2 20151029; CA 2946742 A1 20151029; EP 3134093 A2 20170301; EP 3134093 A4 20171220; EP 3134093 B1 20200909; US 11103520 B2 20210831; US 2017042919 A1 20170216

DOCDB simple family (application)

US 2015027325 W 20150423; CA 2946742 A 20150423; EP 15783308 A 20150423; US 201515305609 A 20150423