EP 3134528 A4 20171206 - MULTIPLE TARGETED RNAI FOR THE TREATMENT OF CANCERS
Title (en)
MULTIPLE TARGETED RNAI FOR THE TREATMENT OF CANCERS
Title (de)
MEHRFACH ANGEZIELTE RNAI ZUR KREBSBEHANDLUNG
Title (fr)
ARNI À CIBLES MULTIPLES PERMETTANT LE TRAITEMENT DE CANCERS
Publication
Application
Priority
- US 201461984614 P 20140425
- US 2015027638 W 20150424
Abstract (en)
[origin: CN106661576A] The present invention includes compositions and methods for making and using a RNAi capable of reducing expression of two or more genes, comprising: a first RNAi molecule that reduces the expression of a first target gene; a second RNAi molecule that reduces the expression of the first or a second target gene; and optionally a third RNAi molecule that reduces the expression of the first, the second, or a third target gene, wherein the RNAi molecules reduce the expression level of, e.g., mutated KRAS, SRC-3, EGFR, PIK3, NCOA3, or ERalphal, and can be, e.g., miRNAs, shRNAs, or bifunctional shRNAs.
IPC 8 full level
C12N 15/113 (2010.01); A61K 48/00 (2006.01); C12N 5/10 (2006.01)
CPC (source: EP US)
A61K 31/7088 (2013.01 - EP US); A61K 31/7105 (2013.01 - EP); A61K 31/713 (2013.01 - EP); A61K 45/06 (2013.01 - EP US); C12N 15/1135 (2013.01 - EP US); C12N 15/1138 (2013.01 - EP); C12Q 1/6886 (2013.01 - EP US); G01N 33/5011 (2013.01 - EP US); A61K 9/0019 (2013.01 - EP); A61K 9/127 (2013.01 - EP); C12N 2310/14 (2013.01 - EP US); C12N 2310/51 (2013.01 - EP); C12N 2310/531 (2013.01 - EP US); C12N 2320/31 (2013.01 - EP US); C12Q 2600/136 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US)
Citation (search report)
- [Y] WO 2013170071 A1 20131114 - GRADALIS INC [US]
- [Y] WO 2013148824 A1 20131003 - GRADALIS INC [US], et al
- [A] US 2013259926 A1 20131003 - RAO DONALD [US], et al
- [A] RAO DONALD D ET AL: "Bifunctional short hairpin RNA (bi-shRNA): design and pathway to clinical application.", METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.), vol. 942, 2013, pages 259 - 278, XP009501123, ISSN: 1940-6029
- [XOP] LONARD DAVID M ET AL: "Preclinical Evaluation of Triple Oncogene-Targeting Bifunctional Small Hairpin RNAs Designed To Simultaneously Target Steroid Receptor Coactivator-3 (SRC-3), EGFR and KRAS", MOLECULAR THERAPY, vol. 22, no. Suppl.1, 659, May 2014 (2014-05-01), pages S255, XP009187241, ISSN: 1525-0016
- See references of WO 2015164818A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
AR 101440 A1 20161221; CN 106661576 A 20170510; EP 3134528 A1 20170301; EP 3134528 A4 20171206
DOCDB simple family (application)
AR P150101261 A 20150427; CN 201580022432 A 20150424; EP 15783597 A 20150424