EP 3140274 A1 20170315 - NAPHTHAQUINONE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Title (en)
NAPHTHAQUINONE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Title (de)
NAPHTHACHINON-METHYLTRANSFERASE-HEMMER UND VERWENDUNGEN DAVON
Title (fr)
INHIBITEURS DE NAPHTAQUINONE MÉTHYLTRANSFÉRASE ET LEURS UTILISATIONS
Publication
Application
Priority
- US 201461990905 P 20140509
- US 201462033938 P 20140806
- US 2015029977 W 20150508
Abstract (en)
[origin: WO2015172076A1] Provided herein are compounds of (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions and methods involving the inventive compounds for the treatment of proliferative diseases (e.g., cancer (e.g., leukemia, breast cancer, melanoma, metastatic cancer) and diseases associated with inappropriate SET8 activity. Also provided are methods for inhibiting SET8 and methods for labelling SET8.
IPC 8 full level
C07C 50/10 (2006.01); C07C 50/12 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 43/00 (2017.12); C07C 50/12 (2013.01); C07C 50/14 (2013.01); C07C 233/32 (2013.01); C07C 323/22 (2013.01); C07C 323/30 (2013.01); C07D 215/38 (2013.01); C07D 217/02 (2013.01); C07D 243/08 (2013.01); C07D 295/116 (2013.01); C09B 13/02 (2013.01); C07C 2601/14 (2017.04); C07C 2602/10 (2017.04)
Citation (search report)
See references of WO 2015172076A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015172076 A1 20151112; AU 2015255692 A1 20161103; CA 2946609 A1 20151112; EP 3140274 A1 20170315; JP 2017515900 A 20170615
DOCDB simple family (application)
US 2015029977 W 20150508; AU 2015255692 A 20150508; CA 2946609 A 20150508; EP 15788940 A 20150508; JP 2017511562 A 20150508