EP 3140324 A1 20170315 - O-ACETYLATED HIGH MOLECULAR WEIGHT POLYGALACTURONIC ACIDS AND THEIR USE AS VI POLYSACCHARIDE VACCINE
Title (en)
O-ACETYLATED HIGH MOLECULAR WEIGHT POLYGALACTURONIC ACIDS AND THEIR USE AS VI POLYSACCHARIDE VACCINE
Title (de)
O-ACETYLIERTE HOCHMOLEKULAREN POLYGALAKTURONSÄUREN UND IHRE VERWENDUNG ALS VI-POLYSACCHARIDIMPFSTOFF
Title (fr)
ACIDES POLYGALACTURONIQUES O-ACÉTYLÉS DE HAUT POIDS MOLÉCULAIRE ET LEUR UTILISATION EN TANT QUE VACCIN POLYSACCHARIDIQUE CONTRE LE VI
Publication
Application
Priority
- US 201461990493 P 20140508
- US 2015029979 W 20150508
Abstract (en)
[origin: WO2015172077A1] The instant disclosure provides O-acetylated high molecular weight polygalacturonic acids or pharmaceutically acceptable salts thereof, having at least one of: (a) a molecular weight greater than 1 x 106 Da; (b) a degree of mefhylation less than about 10% per mole; and (c) an intervening rhamnose content ranging from about 2% to about 15% per mole, useful as a synthetic immunogenic Vi antigen. The instant disclosure further provides methods of preparing an O-acetylated high molecular weight polygalacturonic acid or pharmaceutically acceptable salt thereof of, pharmaceutical compositions and/or vaccine compositions comprising the same, and methods of immunization using any of the foregoing.
IPC 8 full level
A61K 31/732 (2006.01); A61P 31/04 (2006.01); C08B 37/00 (2006.01)
CPC (source: CN EP)
A61K 39/0275 (2013.01 - CN); A61P 31/04 (2017.12 - EP); A61P 37/04 (2017.12 - EP); C08B 37/0045 (2013.01 - CN EP)
Citation (search report)
See references of WO 2015172077A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015172077 A1 20151112; WO 2015172077 A8 20160128; AU 2015255693 A1 20161103; CA 2946900 A1 20151112; CN 106459225 A 20170222; EP 3140324 A1 20170315; JP 2017514961 A 20170608
DOCDB simple family (application)
US 2015029979 W 20150508; AU 2015255693 A 20150508; CA 2946900 A 20150508; CN 201580023307 A 20150508; EP 15723634 A 20150508; JP 2016566668 A 20150508