EP 3145502 B1 20220706 - TRANSDERMAL DELIVERY SYSTEM CONTAINING ROTIGOTINE
Title (en)
TRANSDERMAL DELIVERY SYSTEM CONTAINING ROTIGOTINE
Title (de)
TRANSDERMALES ABGABESYSTEM MIT ROTIGOTIN
Title (fr)
SYSTÈME D'ADMINISTRATION TRANSDERMIQUE CONTENANT DE LA ROTIGOTINE
Publication
Application
Priority
- EP 14169009 A 20140520
- EP 2015061099 W 20150520
Abstract (en)
[origin: WO2015177204A1] Transdermal therapeutic system for the transdermal administration of rotigotine containing an therapeutically effective amount of rotigotine base in a self-adhesive layer structure, comprising A) a backing layer, and B) a rotigotine-containing biphasic layer, the bi phasic layer having a) an outer phase having a composition comprising 75% to 100% of a polymer or a polymer mixture, and b) an inner phase having a composition comprising rotigotine base, wherein the inner phase forms dispersed deposits in the outer phase, and wherein the inner phase comprises i. rotigotine base, and ii. a polymer mixture comprising at least two hydrophilic polymers selected from at least two of the polymer groups: - polyvinylpyrrolidones having a K- Value of at least 80, or from 80 to 200, - polyvinylpyrrolidones having a K- Value of less than 80, or from 10 to 79, - copolymers of vinyl caprolactam, vinylacetate and ethylene glycol, - copolymers of vinylpyrrolidone and vinylacetate, - copolymers of ethylene and vinylacetate, - polyethylene glycols, - polypropylene glycols, - acrylic polymers, - modified celluloses, wherein the polymer mixture in the inner phase is present in an amount sufficient so that said rotigotine base forms a solid solution with the polymer mixture in the inner phase, and C) optionally an additional skin contact layer.
IPC 8 full level
A61K 9/70 (2006.01); A61K 31/381 (2006.01)
CPC (source: CN EP US)
A61K 9/0014 (2013.01 - CN US); A61K 9/7053 (2013.01 - US); A61K 9/7061 (2013.01 - CN EP US); A61K 9/7069 (2013.01 - CN EP US); A61K 9/7084 (2013.01 - CN EP US); A61K 9/7092 (2013.01 - US); A61K 31/381 (2013.01 - CN EP US); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2015177204 A1 20151126; BR 112016027149 A2 20170815; BR 112016027149 A8 20210629; CA 2948220 A1 20151126; CA 2948220 C 20230620; CN 106456566 A 20170222; CN 106456566 B 20200616; EP 3145502 A1 20170329; EP 3145502 B1 20220706; ES 2924899 T3 20221011; JP 2017515869 A 20170615; JP 6573913 B2 20190911; US 11633367 B2 20230425; US 2017105945 A1 20170420; US 2023248661 A1 20230810
DOCDB simple family (application)
EP 2015061099 W 20150520; BR 112016027149 A 20150520; CA 2948220 A 20150520; CN 201580026249 A 20150520; EP 15723245 A 20150520; ES 15723245 T 20150520; JP 2016568496 A 20150520; US 201515312509 A 20150520; US 202318189773 A 20230324