EP 3147667 A1 20170329 - ANALYSIS OF THE MOLECULAR WEIGHT DISTRIBUTION OF COMPLEX POLYPEPTIDE MIXTURES

Title (en)

ANALYSIS OF THE MOLECULAR WEIGHT DISTRIBUTION OF COMPLEX POLYPEPTIDE MIXTURES

Title (de)

ANALYSE DER MOLEKULARGEWICHTSVERTEILUNG VON KOMPLEXEN POLYPEPTIDMISCHUNGEN

Title (fr)

ANALYSE DE LA DISTRIBUTION DU POIDS MOLÉCULAIRE DE MÉLANGES DE POLYPEPTIDES COMPLEXES

Publication

EP 3147667 A1 20170329 (EN)

Application

EP 15186742 A 20150924

Priority

EP 15186742 A 20150924

Abstract (en)

The present invention relates to simple size exclusion chromatography (SEC) analytical methods useful for the assessment of accurate molecular weight distributions (MWDs) of certain polypeptide mixtures known as glatiramoids. The use of a SEC method based on one or more broad MWD standards furnishes the absolute (not relative) molecular weight distribution profile of complex polypeptide mixtures like, for instance, the glatiramer acetate (GA) polymer.

IPC 8 full level

G01N 33/68 (2006.01)

CPC (source: EP US)

G01N 33/6803 (2013.01 - EP US); G01N 33/6848 (2013.01 - US)

Citation (applicant)

US 6514938 B1 20030204 - GAD ALEXANDER [IL], et al
US 6800287 B2 20041005 - GAD ALEXANDER [IL], et al
US 7074580 B2 20060711 - GAD ALEXANDER [IL], et al
US 7163802 B2 20070116 - GAD ALEXANDER [IL], et al
US 7615359 B2 20091110 - GAD ALEXANDER [IL], et al
US 8399211 B2 20130319 - GAD ALEXANDER [IL], et al
US 2007059798 A1 20070315 - GAD ALEXANDER [IL], et al
US 2014045740 A1 20140213 - GLAJCH JOSEPH [US], et al
US 3849550 A 19741119 - TEITELBAUM D, et al
US 5800808 A 19980901 - KONFINO ELIEZER [IL], et al
S. MORI; H.G. BARTH: "Size Exclusion Chromatography", 1999, SPRINGER, pages: 101 - 104
P. STAHL; C. WERMUTH: "Handbook of pharmaceutical salts", 2008, WILEY-VCH, pages: 127 - 133
OLIA ET AL., J. PHAN . BIOMED. ANAL., vol. 25, 2001, pages 833 - 841

Citation (search report)

[X] US 2002115103 A1 20020822 - GAD ALEXANDER [IL], et al
[XD] US 2007059798 A1 20070315 - GAD ALEXANDER [IL], et al
[X] WO 2012123959 A2 20120920 - USV LTD [IN], et al
[X] WO 2012016042 A2 20120202 - REDDYS LAB LTD DR [IN], et al
[X] WO 0018794 A1 20000406 - YEDA RES & DEV [IL], et al
[X] ANONYMOUS: "Analysis of therapeutic proteins and peptides using multiangle light scattering coupled to ultra high performance liquid chromatography - Espinosa-de la Garza - 2015 - Journal of Separation Science - Wiley Online Library", 1 May 2015 (2015-05-01), XP055247908, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/doi/10.1002/jssc.201400863/full> [retrieved on 20160205]

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3147667 A1 20170329; EP 3147667 B1 20190612; ES 2744179 T3 20200224; US 10234461 B2 20190319; US 2017089916 A1 20170330

DOCDB simple family (application)

EP 15186742 A 20150924; ES 15186742 T 20150924; US 201615273718 A 20160923