EP 3152195 A4 20171213 - MTH1 INHIBITORS FOR TREATMENT OF CANCER
Title (en)
MTH1 INHIBITORS FOR TREATMENT OF CANCER
Title (de)
MTH1-INHIBITOREN ZUR BEHANDLUNG VON KREBS
Title (fr)
INHIBITEURS MTH1 POUR LE TRAITEMENT DU CANCER
Publication
Application
Priority
- SE 1450680 A 20140604
- SE 2015050653 W 20150604
Abstract (en)
[origin: WO2015187088A1] A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer.
IPC 8 full level
C07D 239/48 (2006.01); A61K 31/506 (2006.01); A61P 35/00 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP US)
A61K 31/505 (2013.01 - EP US); A61K 31/506 (2013.01 - EP US); A61K 31/517 (2013.01 - EP US); A61K 31/52 (2013.01 - EP US); A61K 31/53 (2013.01 - EP US); A61K 31/5377 (2013.01 - EP US); A61K 31/538 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); C07D 239/48 (2013.01 - EP US); C07D 401/04 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 403/04 (2013.01 - EP US); C07D 403/12 (2013.01 - EP US); C07D 405/04 (2013.01 - EP US); C07D 405/12 (2013.01 - EP US); C07D 409/04 (2013.01 - EP US); C07D 413/12 (2013.01 - EP US); C07D 413/14 (2013.01 - EP US); C07D 417/12 (2013.01 - EP US); C07D 473/16 (2013.01 - EP US); C07D 473/34 (2013.01 - EP US); C07D 487/04 (2013.01 - EP US); C07D 491/044 (2013.01 - EP US); C07D 491/048 (2013.01 - EP US)
Citation (search report)
- [I] HELGE GAD ET AL: "MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool", NATURE, vol. 508, no. 7495, 2 April 2014 (2014-04-02), pages 215 - 221, XP055140550, ISSN: 0028-0836, DOI: 10.1038/nature13181
- [IP] SALEH, A. ET AL.: "Development and validation of method for TH588 and th287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 104, 15 November 2014 (2014-11-15), pages 1 - 11, XP002775303
- See references of WO 2015187088A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2015187088 A1 20151210; AU 2015268961 A1 20170112; AU 2015268961 B2 20190912; AU 2015268961 B9 20191010; CA 2949785 A1 20151210; EP 3152195 A1 20170412; EP 3152195 A4 20171213; US 10179790 B2 20190115; US 2017197976 A1 20170713
DOCDB simple family (application)
SE 2015050653 W 20150604; AU 2015268961 A 20150604; CA 2949785 A 20150604; EP 15803776 A 20150604; US 201515315461 A 20150604