EP 3157919 A1 20170426 - BET-PROTEIN INHIBITING 3,4-DIHYDROPYRIDO[2,3-B]PYRAZINONES WITH META-SUBSTITUTED AROMATIC AMINO- OR ETHER GROUPS
Title (en)
BET-PROTEIN INHIBITING 3,4-DIHYDROPYRIDO[2,3-B]PYRAZINONES WITH META-SUBSTITUTED AROMATIC AMINO- OR ETHER GROUPS
Title (de)
BET-PROTEININHIBITORISCHE 3,4-DIHYDROPYRIDO[2,3-B]PYRAZINONE MIT META-SUBSTITUIERTER AROMATISCHER AMINO- ODER ETHERGRUPPE
Title (fr)
3,4-DIHYDROPYRIDO[2,3-B]PYRAZINONES INHIBITRICES DE PROTÉINE BET, À GROUPE ÉTHER OU AMINO AROMATIQUE META-SUBSTITUÉ
Publication
Application
Priority
- EP 14173045 A 20140618
- EP 2015063278 W 20150615
Abstract (en)
[origin: WO2015193219A1] The invention relates to BET-protein-inhibiting, in particular BRD4-inhibiting 3,4-dihydropyrido[2,3-b]pyrazinones with meta-substituted aromatic amino or ether groups of general formula (I), in which A, X, Y, R1, R2, R3, R4, R5, R6, and n have the meanings indicated in the description, pharmaceutical agents containing the claimed compounds, and the prophylactic and therapeutic use of said pharmaceutical agents in the case of hyperproliferative diseases, in particular in the case of tumor diseases. The invention further relates to the use of BET protein inhibitors in the case of viral infections, neurodegenerative diseases, inflammatory diseases, and atherosclerotic diseases and in male fertility control.
IPC 8 full level
C07D 471/04 (2006.01); A61P 9/10 (2006.01); A61P 15/16 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01)
CPC (source: CN EP US)
A61K 31/4985 (2013.01 - EP US); A61P 9/10 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 15/16 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 471/04 (2013.01 - CN EP US)
Citation (search report)
See references of WO 2015193219A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2015193219 A1 20151223; CA 2952526 A1 20151223; CN 106573931 A 20170419; EP 3157919 A1 20170426; HK 1232226 A1 20180105; JP 2017519760 A 20170720; US 2017121322 A1 20170504
DOCDB simple family (application)
EP 2015063278 W 20150615; CA 2952526 A 20150615; CN 201580044412 A 20150615; EP 15729444 A 20150615; HK 17105942 A 20170615; JP 2016573534 A 20150615; US 201515317925 A 20150615