EP 3164412 A4 20180328 - PHARMACEUTICAL COMPOSITION COMPRISING RECOMBINANT HEMOGLOBIN PROTEIN OR SUBUNIT-BASED THERAPEUTIC AGENT FOR CANCER TARGETING TREATMENT
Title (en)
PHARMACEUTICAL COMPOSITION COMPRISING RECOMBINANT HEMOGLOBIN PROTEIN OR SUBUNIT-BASED THERAPEUTIC AGENT FOR CANCER TARGETING TREATMENT
Title (de)
PHARMAZEUTISCHE ZUSAMMENSETZUNG MIT THERAPEUTIKUM AUF BASIS VON REKOMBINANTEM HÄMOGLOBINPROTEIN ODER EINER UNTEREINHEIT FÜR KREBS-TARGETING-BEHANDLUNG
Title (fr)
COMPOSITION PHARMACEUTIQUE COMPRENANT UN AGENT THÉRAPEUTIQUE À BASE D'UNE PROTÉINE OU D'UNE SOUS-UNITÉ D'HÉMOGLOBINE RECOMBINÉE POUR TRAITEMENT CIBLÉ DU CANCER
Publication
Application
Priority
- US 201462019925 P 20140702
- US 201514752999 A 20150628
- CN 2015083041 W 20150701
Abstract (en)
[origin: US2016000864A1] The present invention provides a pharmaceutical composition containing recombinant hemoglobin protein or tetramer or dimer or subunit for tissue oxygenation and treating cancer. The recombinant hemoglobin protein or tetramer or dimer or subunit-based therapeutic agent is also effective for treating cancer. The recombinant hemoglobin or tetramer or dimer or its subunit moiety can target cancer cells and the therapeutic moiety (i.e. active agent/therapeutic drug) can kill the cancer cells efficiently. The recombinant hemoglobin or tetramer or dimer or its subunit-based therapeutic agent used in the present invention can be used in the treatment of various cancers such as pancreatic cancer, leukemia, head and neck cancer, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal cancer, esophageal cancer, prostate cancer, stomach cancer and brain cancer. The composition can be used alone or in combination with other therapeutic agent(s) such as chemotherapeutic agent, radiotherapeutic agent, anti-cancer protein drug to give a synergistic effect on cancer treatment, inhibiting metastasis and/or reducing recurrence.
IPC 8 full level
C07K 14/805 (2006.01); A61K 31/4188 (2006.01); A61K 31/505 (2006.01); A61K 33/24 (2006.01); A61K 38/42 (2006.01); A61K 51/08 (2006.01); A61P 7/08 (2006.01); A61P 35/00 (2006.01); G01N 33/574 (2006.01); A61K 101/00 (2006.01)
CPC (source: EP KR US)
A61K 31/7068 (2013.01 - EP KR US); A61K 38/1709 (2013.01 - US); A61K 38/42 (2013.01 - EP KR US); A61K 45/06 (2013.01 - EP KR US); A61K 47/6445 (2017.07 - EP KR US); A61P 7/08 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07K 14/805 (2013.01 - EP KR US); A61K 2300/00 (2013.01 - KR)
Citation (search report)
- [XY] US 7932356 B1 20110426 - WONG BING LOU [US], et al
- [XY] US 2011295225 A1 20111201 - WONG BING LOU [US], et al
- See references of WO 2016000616A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 2016000864 A1 20160107; US 9814759 B2 20171114; AR 101101 A1 20161123; AU 2015283394 A1 20170119; AU 2015283394 B2 20190411; CA 2953173 A1 20160107; CN 106715468 A 20170524; EP 3164412 A1 20170510; EP 3164412 A4 20180328; HK 1232242 A1 20180105; KR 20170026485 A 20170308; SG 10201807554Q A 20181030; SG 11201610947U A 20170127; TW 201613960 A 20160416; TW I633118 B 20180821; UY 36202 A 20160129; WO 2016000616 A1 20160107
DOCDB simple family (application)
US 201514752999 A 20150628; AR P150102131 A 20150702; AU 2015283394 A 20150701; CA 2953173 A 20150701; CN 2015083041 W 20150701; CN 201580047951 A 20150701; EP 15815035 A 20150701; HK 17106011 A 20170616; KR 20177001611 A 20150701; SG 10201807554Q A 20150701; SG 11201610947U A 20150701; TW 104121109 A 20150630; UY 36202 A 20150702