Global Patent Index - EP 3169372 A4

EP 3169372 A4 20180321 - CONTROLLABLE SELF-ANNEALING MICROGEL PARTICLES FOR BIOMEDICAL APPLICATIONS

Title (en)

CONTROLLABLE SELF-ANNEALING MICROGEL PARTICLES FOR BIOMEDICAL APPLICATIONS

Title (de)

STEUERBARE SELBSTHÄRTENDE MIKROGELPARTIKEL FÜR BIOMEDIZINISCHE ANWENDUNGEN

Title (fr)

PARTICULES DE MICROGEL AUTO-RECUITES CONTRÔLABLES POUR DES APPLICATIONS BIOMÉDICALES

Publication

EP 3169372 A4 20180321 (EN)

Application

EP 15821310 A 20150717

Priority

  • US 201462025844 P 20140717
  • US 201462059463 P 20141003
  • US 201562103002 P 20150113
  • US 2015040962 W 20150717

Abstract (en)

[origin: WO2016011387A1] A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

IPC 8 full level

A61L 15/42 (2006.01); A61L 15/44 (2006.01); A61L 15/60 (2006.01); A61L 26/00 (2006.01); A61L 27/18 (2006.01); A61L 27/58 (2006.01)

CPC (source: EP IL KR US)

A61K 9/06 (2013.01 - IL US); A61K 31/795 (2013.01 - IL US); A61K 47/62 (2017.08 - IL US); A61L 26/0019 (2013.01 - EP IL KR US); A61L 26/0047 (2013.01 - IL KR US); A61L 26/0066 (2013.01 - IL KR US); A61L 26/008 (2013.01 - EP IL US); A61L 26/0085 (2013.01 - EP IL KR US); A61L 26/009 (2013.01 - EP IL US); A61L 27/18 (2013.01 - EP IL US); A61L 27/227 (2013.01 - IL US); A61L 27/52 (2013.01 - IL KR US); A61L 27/54 (2013.01 - IL KR US); A61L 27/56 (2013.01 - IL KR US); A61L 27/58 (2013.01 - EP IL US); A61L 2300/252 (2013.01 - IL US); A61L 2300/412 (2013.01 - IL US); A61L 2400/06 (2013.01 - IL KR US); A61L 2430/00 (2013.01 - IL US); A61L 2430/34 (2013.01 - EP IL KR US)

C-Set (source: EP US)

  1. A61L 27/18 + C08L 71/02
  2. A61L 26/0019 + C08L 71/02

Citation (search report)

  • [X] US 2008193536 A1 20080814 - KHADEMHOSSEINI ALIREZA [US], et al
  • [A] WO 2012155110 A1 20121115 - MASSACHUSETTS INST TECHNOLOGY [US], et al
  • [XP] DONALD R. GRIFFIN ET AL: "Accelerated wound healing by injectable microporous gel scaffolds assembled from?annealed building blocks", NATURE MATERIALS, vol. 14, no. 7, 1 July 2015 (2015-07-01), GB, pages 737 - 744, XP055430241, ISSN: 1476-1122, DOI: 10.1038/nmat4294
  • [A] PARK YONGDOO ET AL: "Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly(ethylene glycol)-based hydrogels as a scaffold for cartilage repair", TISSUE ENGINEERING, LARCHMONT, NY, US, vol. 10, no. 3-4, 1 March 2004 (2004-03-01), pages 515 - 522, XP002464246, ISSN: 1076-3279, DOI: 10.1089/107632704323061870
  • [A] JONATHAN LAM ET AL: "Design of cell-matrix interactions in hyaluronic acid hydrogel scaffolds", ACTA BIOMATERIALIA, vol. 10, no. 4, 1 April 2014 (2014-04-01), AMSTERDAM, NL, pages 1571 - 1580, XP055449152, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2013.07.025
  • [A] CHIEN-CHI LIN ET AL: "PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, vol. 26, no. 3, 18 December 2008 (2008-12-18), pages 631 - 643, XP019686137, ISSN: 1573-904X
  • See also references of WO 2016011387A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2016011387 A1 20160121; AU 2015289474 A1 20170202; AU 2015289474 B2 20191205; BR 112017000813 A2 20171205; BR 112017000813 B1 20210316; CA 2955357 A1 20160121; CN 106714854 A 20170524; CN 106714854 B 20200904; CN 111939316 A 20201117; CN 111939316 B 20220805; EP 3169372 A1 20170524; EP 3169372 A4 20180321; IL 250092 A0 20170330; IL 250092 B 20210531; IL 282559 A 20210630; IL 282559 B 20220701; JP 2017522113 A 20170810; JP 2020075150 A 20200521; JP 2022177012 A 20221130; JP 6651500 B2 20200219; JP 7188779 B2 20221213; KR 102264607 B1 20210614; KR 102421923 B1 20220718; KR 102614915 B1 20231219; KR 20170031741 A 20170321; KR 20210072133 A 20210616; KR 20220104071 A 20220725; KR 20230173741 A 20231227; US 10912860 B2 20210209; US 11464886 B2 20221011; US 2016279283 A1 20160929; US 2017368224 A1 20171228; US 2018078671 A1 20180322; US 2019151497 A1 20190523; US 2020085859 A1 20200319; US 2021138105 A1 20210513; US 2023190995 A1 20230622

DOCDB simple family (application)

US 2015040962 W 20150717; AU 2015289474 A 20150717; BR 112017000813 A 20150717; CA 2955357 A 20150717; CN 201580049478 A 20150717; CN 202010830676 A 20150717; EP 15821310 A 20150717; IL 25009217 A 20170112; IL 28255921 A 20210422; JP 2017502712 A 20150717; JP 2020008247 A 20200122; JP 2022134723 A 20220826; KR 20177004012 A 20150717; KR 20217017499 A 20150717; KR 20227024066 A 20150717; KR 20237043035 A 20150717; US 201615179151 A 20160610; US 201715701113 A 20170911; US 201715829440 A 20171201; US 201916264466 A 20190131; US 201916596312 A 20191008; US 202117144158 A 20210108; US 202217935096 A 20220924