EP 3174541 A1 20170607 - THYMINE DERIVATIVES AND QUINAZOLINE-DIONE DERIVATIVES FOR THE INHIBITION OF HSP27
Title (en)
THYMINE DERIVATIVES AND QUINAZOLINE-DIONE DERIVATIVES FOR THE INHIBITION OF HSP27
Title (de)
THYMIN- UND CHINAZOLIN-DION-DERIVATE ZUR HEMMUNG VON HSP27
Title (fr)
DÉRIVÉS DE LA THYMINE ET DE LA CHINAZOLINE-DIONE POUR INHIBER HSP27
Publication
Application
Priority
- DE 102014214798 A 20140728
- DE 102014214799 A 20140728
- EP 2015067312 W 20150728
Abstract (en)
[origin: WO2016016267A1] The present invention relates to novel HSP27 inhibitors, in particular purine derivatives according to general formula (I) or (II) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.
IPC 8 full level
A61K 31/513 (2006.01); A61K 31/5415 (2006.01)
CPC (source: CN EP US)
A61K 31/513 (2013.01 - EP US); A61K 31/522 (2013.01 - CN EP US); A61K 31/5415 (2013.01 - CN EP US); A61K 31/708 (2013.01 - CN EP US); A61K 45/06 (2013.01 - EP US); A61P 35/00 (2017.12 - EP US); C07D 239/553 (2013.01 - CN); C07D 239/96 (2013.01 - CN); C07D 279/22 (2013.01 - CN); C07D 279/26 (2013.01 - CN); C07D 403/12 (2013.01 - CN); C07D 473/30 (2013.01 - CN); C07D 519/00 (2013.01 - CN); C07F 9/65616 (2013.01 - CN); C07H 19/073 (2013.01 - CN)
Citation (search report)
See references of WO 2016016268A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2016016267 A1 20160204; CN 107073003 A 20170818; CN 107074791 A 20170818; EP 3174541 A1 20170607; EP 3174545 A1 20170607; US 10940150 B2 20210309; US 2017216297 A1 20170803; US 2018207160 A1 20180726; WO 2016016268 A1 20160204
DOCDB simple family (application)
EP 2015067311 W 20150728; CN 201580040458 A 20150728; CN 201580040473 A 20150728; EP 15744196 A 20150728; EP 15744197 A 20150728; EP 2015067312 W 20150728; US 201515329693 A 20150728; US 201515329722 A 20150728