Global Patent Index - EP 3177595 A4

EP 3177595 A4 20171227 - ASYMMETRIC BISAMINOQUINOLINES AND BISAMINOQUINOLINES WITH VARIED LINKERS AS AUTOPHAGY INHIBITORS FOR CANCER AND OTHER THERAPY

Title (en)

ASYMMETRIC BISAMINOQUINOLINES AND BISAMINOQUINOLINES WITH VARIED LINKERS AS AUTOPHAGY INHIBITORS FOR CANCER AND OTHER THERAPY

Title (de)

ASYMMETRISCHE BISAMINOCHINOLINE UND BISAMINOCHINOLINE MIT UNTERSCHIEDLICHEN LINKERN ALS AUTOPHAGIEINHIBITOREN FÜR KREBS- UND ANDERE THERAPIEN

Title (fr)

BISAMINOQUINOLINES ASYMÉTRIQUES ET BISAMINOQUINOLINES COMPORTANT DIVERSES SÉQUENCES DE LIAISON POUVANT ÊTRE UTILISÉES EN TANT QU'INHIBITEURS DE L'AUTOPHAGIE POUR LE TRAITEMENT DU CANCER ET D'AUTRES MALADIES

Publication

EP 3177595 A4 20171227 (EN)

Application

EP 15830607 A 20150807

Priority

  • US 201462034897 P 20140808
  • US 2015044282 W 20150807

Abstract (en)

[origin: WO2016022956A1] The invention provides novel asymmetric and symmetric bisaminoquinolmes and related compounds, methods of treatment and syntheses. The novel compounds exhibit effective anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.

IPC 8 full level

C07D 215/42 (2006.01); A61K 31/436 (2006.01); A61K 31/4375 (2006.01); A61K 31/4545 (2006.01); A61K 31/4706 (2006.01); A61K 31/4709 (2006.01); A61K 31/4745 (2006.01); A61K 31/4995 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 31/704 (2006.01); A61K 31/7056 (2006.01); A61P 19/04 (2006.01); A61P 29/00 (2006.01); A61P 31/06 (2006.01); A61P 33/06 (2006.01); A61P 35/00 (2006.01); C07D 215/46 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01)

CPC (source: EP US)

A61K 31/436 (2013.01 - US); A61K 31/4375 (2013.01 - US); A61K 31/4545 (2013.01 - US); A61K 31/4706 (2013.01 - EP US); A61K 31/4709 (2013.01 - EP US); A61K 31/4745 (2013.01 - US); A61K 31/4995 (2013.01 - US); A61K 31/506 (2013.01 - US); A61K 31/517 (2013.01 - US); A61K 31/519 (2013.01 - US); A61K 31/704 (2013.01 - US); A61K 31/7056 (2013.01 - US); A61P 19/04 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/06 (2017.12 - EP); A61P 33/06 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07D 215/46 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); Y02A 50/30 (2017.12 - EP US)

C-Set (source: EP US)

  1. A61K 31/4706 + A61K 2300/00
  2. A61K 31/4709 + A61K 2300/00

Citation (search report)

  • [X] WO 2004091485 A2 20041028 - TAIGEN BIOTECHNOLOGY CO LTD [CN], et al
  • [X] US 5756517 A 19980526 - SCHOHE-LOOP RUDOLF [DE], et al
  • [X] IGOR M. OPSENICA ET AL: "4-Amino-7-chloroquinolines: Probing Ligand Efficiency Provides Botulinum Neurotoxin Serotype A Light Chain Inhibitors with Significant Antiprotozoal Activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 14, 25 July 2013 (2013-07-25), pages 5860 - 5871, XP055425221, ISSN: 0022-2623, DOI: 10.1021/jm4006077
  • [XI] Q. MCAFEE ET AL: "Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, no. 21, 22 May 2012 (2012-05-22), pages 8253 - 8258, XP055166131, ISSN: 0027-8424, DOI: 10.1073/pnas.1118193109
  • [XI] BIRANDRA K. SINHA ET AL: "Synthesis and antitumor properties of bis(quinaldine) derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 11, 1 November 1977 (1977-11-01), pages 1528 - 1531, XP055425243, ISSN: 0022-2623, DOI: 10.1021/jm00221a037
  • [X] JONATHAN L. VENNERSTROM ET AL: "Bisquinolines. 2. Antimalarial N , N -Bis(7-chloroquinolin-4-yl)heteroalkanediamines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 22, 1 October 1998 (1998-10-01), pages 4360 - 4364, XP055135948, ISSN: 0022-2623, DOI: 10.1021/jm9803828
  • [XI] ZHANG ET AL: "Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives", BIOMEDICINE AND PHARMACOTHERAPY, ELSEVIER, FR, vol. 62, no. 2, 1 February 2008 (2008-02-01), pages 65 - 69, XP022475873, ISSN: 0753-3322, DOI: 10.1016/J.BIOPHA.2007.04.007
  • [X] SOPHIE GIRAULT ET AL: "Natiplasmodial activity and cytotoxicity of bis-, tris- and tetraquinolines with linear or cyclic amino linkers", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 44, no. 11, 1 November 2001 (2001-11-01), pages 1658 - 1665, XP002730047, ISSN: 0022-2623, [retrieved on 20010427], DOI: 10.1021/JM001096A
  • See references of WO 2016022956A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2016022956 A1 20160211; EP 3177595 A1 20170614; EP 3177595 A4 20171227; EP 3177595 B1 20210224; EP 3848355 A1 20210714; ES 2881048 T3 20211126; US 10221140 B2 20190305; US 11001558 B2 20210511; US 11639335 B2 20230502; US 2017275252 A1 20170928; US 2019248747 A1 20190815; US 2022064118 A1 20220303

DOCDB simple family (application)

US 2015044282 W 20150807; EP 15830607 A 20150807; EP 21158586 A 20150807; ES 15830607 T 20150807; US 201515502330 A 20150807; US 201816201117 A 20181127; US 202117229012 A 20210413