EP 3178932 A1 20170614 - SYNTHETIC MIMICS OF MIR-34

Title (en)

SYNTHETIC MIMICS OF MIR-34

Title (de)

SYNTHETISCHE MIMETIKA VON MIR-34

Title (fr)

MIMÉTIQUES SYNTHÉTIQUES DE MIR-34

Publication

EP 3178932 A1 20170614 (EN)

Application

EP 16195581 A 20120203

Priority

US 201161439280 P 20110203
EP 12703943 A 20120203

Abstract (en)

Embodiments concern methods and compositions involving miR-34 mimics, including miR-34a and miR-34c mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34a sequence and a complementary passenger strand. In additional embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34c sequence and a complementary passenger strand.

IPC 8 full level

C12N 15/113 (2010.01)

CPC (source: EP KR RU US)

A61K 31/713 (2013.01 - EP US); A61K 45/06 (2013.01 - US); A61K 48/00 (2013.01 - KR); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12N 15/113 (2013.01 - EP KR RU US); C12N 2310/11 (2013.01 - KR); C12N 2310/141 (2013.01 - EP KR RU US); C12N 2310/317 (2013.01 - EP KR US); C12N 2310/321 (2013.01 - EP KR RU US)

Citation (applicant)

US 2008050744 A1 20080228 - BROWN DAVID [US], et al
US 14170705 A 20050531
US 27364005 A 20051114
US 2009227533 A1 20090910 - BADER ANDREAS G [US], et al
US 6383808 B1 20020507 - FREIER SUSAN M [US]
US 8902323 W 19890526
US 2005261218 A1 20051124 - ESAU CHRISTINE [US], et al
US 4981957 A 19910101 - LEBLEU BERNARD [FR], et al
US 5118800 A 19920602 - SMITH LLOYD M [US], et al
US 5319080 A 19940607 - LEUMANN CHRISTIAN [CH]
US 5359044 A 19941025 - COOK PHILLIP D [US], et al
US 5393878 A 19950228 - LEUMANN CHRISTIAN [CH]
US 5446137 A 19950829 - MAAG HANS [US], et al
US 5466786 A 19951114 - BUHR CHRIS A [US], et al
US 5514785 A 19960507 - VAN NESS JEFFREY [US], et al
US 5519134 A 19960521 - ACEVEDO OSCAR L [US], et al
US 5567811 A 19961022 - MISIURA KONRAD [PL], et al
US 5576427 A 19961119 - COOK PHILIP D [US], et al
US 5591722 A 19970107 - MONTGOMERY JOHN A [US], et al
US 5597909 A 19970128 - URDEA MICHAEL S [US], et al
US 5610300 A 19970311 - ALTMANN KARL-HEINZ [CH], et al
US 5627053 A 19970506 - USMAN NASSIM [US], et al
US 5639873 A 19970617 - BARASCUT JEAN-LOUIS [FR], et al
US 5646265 A 19970708 - MCGEE DANIEL PETER CLAUDE [US]
US 5658873 A 19970819 - BERTSCH-FRANK BIRGIT [DE], et al
US 5670633 A 19970923 - COOK PHILLIP DAN [US], et al
US 5792747 A 19980811 - SCHALLY ANDREW V [US], et al
US 5700920 A 19971223 - ALTMANN KARL-HEINZ [CH], et al
US 2010267814 A1 20101021 - BENNETT C FRANK [US], et al
US 66712603 A 20030919
US 4704362 A 19871103 - ITAKURA KEIICHI [US], et al
US 5221619 A 19930622 - ITAKURA KEIICHI [US], et al
US 5583013 A 19961210 - ITAKURA KEIICHI [US], et al
EP 0266032 A1 19880504 - BEECHAM GROUP PLC [GB]
US 5705629 A 19980106 - BHONGLE NANDKUMAR [US]
US 4659774 A 19870421 - WEBB THOMAS R [US], et al
US 4816571 A 19890328 - ANDRUS WILLIAM A [US], et al
US 5141813 A 19920825 - NELSON PAUL S [US]
US 5264566 A 19931123 - FROEHLER BRIAN C [US], et al
US 4959463 A 19900925 - FROEHLER BRIAN C [US], et al
US 5428148 A 19950627 - REDDY PARAMESWARA M [US], et al
US 5554744 A 19960910 - BHONGLE NANDKUMAR [US], et al
US 5574146 A 19961112 - REDDY M PARAMESWARA [US], et al
US 5602244 A 19970211 - CARUTHERS MARVIN H [US], et al
US 4683202 A 19870728 - MULLIS KARY B [US]
US 4682195 A 19870721 - YILMAZ HAMZA [US]
US 5645897 A 19970708 - ANDRA JURGEN [DE]
US 5543158 A 19960806 - GREF RUXANDRA [FR], et al
US 5641515 A 19970624 - RAMTOOLA ZEIBUN [IE]
US 5399363 A 19950321 - LIVERSIDGE GARY G [US], et al
US 5846225 A 19981208 - ROSENGART TODD K [US], et al
US 5466468 A 19951114 - SCHNEIDER PETER [CH], et al
US 5075109 A 19911224 - TICE THOMAS R [US], et al
US 4452775 A 19840605 - KENT JOHN S [US]
US 4675189 A 19870623 - KENT JOHN S [US], et al
US 5736152 A 19980407 - DUNN RICHARD L [US]
US 4667013 A 19870519 - REICHLE WALTER T [US]
US 4748034 A 19880531 - DE RHAM OLIVIER [CH]
US 5239660 A 19930824 - OOI YASUSHI [JP]
US 3832253 A 19740827 - DI PALMA G, et al
US 3854480 A 19741217 - ZAFFARONI A
US 5133974 A 19920728 - PARADISSIS GEORGE N [US], et al
US 5407686 A 19950418 - PATEL SATISHCHANDRA P [US], et al
US 5760395 A 19980602 - JOHNSTONE CAROL J [US]
US 4870287 A 19890926 - COLE FRANCIS T [US], et al
US 5801005 A 19980901 - CHEEVER MARTIN A [US], et al
US 5739169 A 19980414 - OCAIN TIMOTHY D [US], et al
US 5830880 A 19981103 - SEDLACEK HANS-HARALD [DE], et al
US 5846945 A 19981208 - MCCORMICK FRANCIS [US]
US 5824311 A 19981020 - GREENE MARK I [US], et al
US 3687808 A 19720829 - MERIGAN THOMAS C JR, et al
"Remington's Pharmaceutical Sciences 15th Edition", 1990, MACK PUBLISHING, pages: 1035 - 1038,157
AUSTIN-WARD; VILLASECA, REVISTA MEDICA DE CHILE, vol. 126, no. 7, 1998, pages 838 - 845
BAGGA ET AL., CELL, vol. 122, no. 4, 2005, pages 553 - 563
BUKOWSKI ET AL., CLINICAL CANCER RES., vol. 4, no. 10, 1998, pages 2337 - 2347
CALIN; CROCE, NAT REV CANCER, vol. 6, no. 11, 2006, pages 857 - 866
CHRISTODOULIDES ET AL., MICROBIOLOGY, vol. 144, 1998, pages 3027 - 3037
DAVIDSON ET AL., J. IMMUNOTHER., vol. 21, no. 5, 1998, pages 389 - 398
DENLI ET AL., TRENDS BIOCHEM. SCI., vol. 28, 2003, pages 196
DILLMAN, CANCER BIOTHER. RADIOPHARM., vol. 14, no. 1, 1999, pages 5 - 10
ESQUELA-KERSCHER; SLACK, NAT REV CANCER, vol. 6, no. 4, 2006, pages 259 - 269
FROEHLER ET AL., NUCLEIC ACIDS RES., vol. 14, no. 13, 1986, pages 5399 - 5407
GRIFFITHS-JONES ET AL., NUCLEIC ACIDS RES., vol. 34, 2006, pages D140 - D144
HANIBUCHI ET AL., INT. J. CANCER, vol. 78, no. 4, 1998, pages 480 - 485
HELLSTRAND ET AL., ACTA ONCOL., vol. 37, no. 4, 1998, pages 347 - 353
HUI; HASHIMOTO, INFECTION IMMUN., vol. 66, no. 11, 1998, pages 5329 - 5336
HU-LIESKOVAN ET AL., CANCER RES., vol. 65, no. 19, 2005, pages 8984 - 92
ITAKURA; RIGGS, SCIENCE, vol. 209, 1980, pages 1401 - 1405
JEFFS ET AL., PHARM RES., vol. 22, no. 3, 2005, pages 362 - 72
JU ET AL., GENE THER., vol. 7, no. 19, 2000, pages 1672 - 1679
LAGOS-QUINTANA ET AL., RNA, vol. 9, no. 2, 2003, pages 175 - 179
LAU ET AL., SCIENCE, vol. 294, no. 5543, 2001, pages 858 - 862
LEE; AMBROS, SCIENCE, vol. 294, no. 5543, 2001, pages 862 - 864
LEE, EMBO J., vol. 21, no. 17, 2002, pages 4663 - 4670
LIM ET AL., NATURE, vol. 433, no. 7027, 2005, pages 769 - 773
MARTIN ET AL., HELV. CHIM. ACTA, vol. 78, 1995, pages 486 - 504
OLSEN ET AL., DEV. BIOL., vol. 216, 1999, pages 671
PIETRAS ET AL., ONCOGENE, vol. 17, no. 17, 1998, pages 2235 - 2249
QIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, no. 24, 1998, pages 14411 - 14416
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual 3rd Ed.,", 2001, COLD SPRING HARBOR LABORATORY PRESS
SAMBROOK ET AL.: "In: DNA microaarays: a molecular cloning manual", 2003, COLD SPRING HARBOR LABORATORY PRESS
SAMBROOK ET AL.: "In: Molecular cloning: a laboratory manual, 2nd Ed.,", 1989, COLD SPRING HARBOR LABORATORY PRESS
SEGGERSON ET AL., DEV. BIOL., vol. 243, 2002, pages 215
WIEMER, EUR J CANCER, vol. 43, no. 10, 2007, pages 1529 - 1544

Citation (search report)

[I] X. LIU ET AL: "Uncovering Growth-Suppressive MicroRNAs in Lung Cancer", CLINICAL CANCER RESEARCH, vol. 15, no. 4, 15 February 2009 (2009-02-15), pages 1177 - 1183, XP055023511, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-08-1355

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2012106591 A1 20120809; AU 2012212023 A1 20130912; AU 2012212023 B2 20170105; AU 2012212023 B9 20170112; BR 112013019853 A2 20170321; CA 2825981 A1 20120809; CL 2013002195 A1 20140530; CN 103476931 A 20131225; EP 2670850 A1 20131211; EP 2670850 B1 20161026; EP 3178932 A1 20170614; IL 227697 A0 20130930; JP 2014506791 A 20140320; JP 2016152804 A 20160825; KR 20140020900 A 20140219; MX 2013008945 A 20140108; MX 342927 B 20161019; MY 165507 A 20180328; RU 2013140634 A 20150310; RU 2615117 C2 20170404; SG 10201600836P A 20160330; SG 192252 A1 20130930; US 2012288933 A1 20121115; US 2014107182 A1 20140417; US 2016053264 A1 20160225; US 8586727 B2 20131119; US 9371526 B2 20160621; ZA 201306518 B 20140528

DOCDB simple family (application)

US 2012023755 W 20120203; AU 2012212023 A 20120203; BR 112013019853 A 20120203; CA 2825981 A 20120203; CL 2013002195 A 20130731; CN 201280016251 A 20120203; EP 12703943 A 20120203; EP 16195581 A 20120203; IL 22769713 A 20130729; JP 2013552671 A 20120203; JP 2016029508 A 20160219; KR 20137023160 A 20120203; MX 2013008945 A 20120203; MY PI2013002871 A 20120203; RU 2013140634 A 20120203; SG 10201600836P A 20120203; SG 2013058466 A 20120203; US 201213365676 A 20120203; US 201314081295 A 20131115; US 201514933118 A 20151105; ZA 201306518 A 20130829