EP 3193873 A1 20170726 - ORALLY ADMINISTRABLE COMPOSITIONS AND METHODS OF DETERRING ABUSE BY INTRANASAL ADMINISTRATION
Title (en)
ORALLY ADMINISTRABLE COMPOSITIONS AND METHODS OF DETERRING ABUSE BY INTRANASAL ADMINISTRATION
Title (de)
ORAL VERABREICHBARE ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERHINDERUNG DES MISSBRAUCHS DURCH INTRANASALE VERABREICHUNG
Title (fr)
COMPOSITION POUR ADMINISTRATION ORALE ET PROCÉDÉS DE PRÉVENTION DES ADDICTIONS PAR ADMINISTRATION INTRANASALE
Publication
Application
Priority
US 2014055616 W 20140915
Abstract (en)
[origin: WO2016043698A1] The present invention provides an orally administrable pharmaceutical composition comprising a drug and one or more pharmaceutically acceptable excipients in an amount sufficient to deter abuse by nasal insufflation, wherein the pharmaceutical composition is configured such that when the pharmaceutical composition is intranasally administered in physically compromised form to a subject, the Cmax and/or AUG of the drug achieved after a time period is lower than the Cmax and/or AUG of the drug achieved after intranasal administration of a physically compromised form of an orally bioequivalent composition not containing one or more pharmaceutically acceptable excipients in an amount sufficient to deter abuse by nasal insufflation.
IPC 8 full level
A61K 31/485 (2006.01)
CPC (source: EP)
A61K 9/0043 (2013.01); A61K 9/2054 (2013.01); A61K 31/137 (2013.01); A61K 31/4468 (2013.01); A61K 31/485 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2016043698 A1 20160324; CA 2961460 A1 20160324; EP 3193873 A1 20170726; EP 3193873 A4 20180530
DOCDB simple family (application)
US 2014055616 W 20140915; CA 2961460 A 20140915; EP 14902242 A 20140915