Global Patent Index - EP 3197437 A4

EP 3197437 A4 20180523 - COMPOSITIONS, METHODS AND KITS FOR TREATMENT OF DIABETES AND/OR HYPERLIPIDEMIA

Title (en)

COMPOSITIONS, METHODS AND KITS FOR TREATMENT OF DIABETES AND/OR HYPERLIPIDEMIA

Title (de)

VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON DIABETES UND/ODER HYPERLIPIDÄMIE

Title (fr)

COMPOSITIONS, MÉTHODES ET KITS DE TRAITEMENT DU DIABÈTE ET/OU DE L'HYPERLIPIDÉMIE

Publication

EP 3197437 A4 20180523 (EN)

Application

EP 15844508 A 20150923

Priority

  • US 201462054921 P 20140924
  • US 2015051793 W 20150923

Abstract (en)

[origin: WO2016049236A1] Compositions, methods and kits for treatment of diabetes and/or hyperlipidemia are provided herein. Such compositions can contain synergizing amounts of leucine and/or one or more leucine metabolites in combination with nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites, and with at least one or more anti-diabetic agents. Such compositions can contain sub-therapeutic amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites, and/or sub-therapeutic amounts of one or more anti-diabetic agents that can achieve the same therapeutic efficacy as therapeutic amounts of said compositions in diabetes and/or hyperlipidemia medicaments. The composition can also reduce the side effects associated with treatment using anti-diabetic agents and/or nicotinic acid.

IPC 8 full level

A61K 31/198 (2006.01); A61K 31/05 (2006.01); A61K 31/155 (2006.01); A61K 31/28 (2006.01); A61K 31/36 (2006.01); A61K 31/455 (2006.01); A61K 31/706 (2006.01); A61K 45/06 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01)

CPC (source: EP US)

A61K 31/05 (2013.01 - EP US); A61K 31/155 (2013.01 - EP US); A61K 31/198 (2013.01 - EP US); A61K 31/28 (2013.01 - EP US); A61K 31/36 (2013.01 - EP US); A61K 31/455 (2013.01 - EP US); A61K 31/706 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 3/06 (2018.01 - EP US); A61P 3/10 (2018.01 - EP US); A61K 2300/00 (2013.01 - US)

C-Set (source: EP US)

  1. A61K 31/455 + A61K 2300/00
  2. A61K 31/198 + A61K 2300/00
  3. A61K 31/706 + A61K 2300/00
  4. A61K 31/36 + A61K 2300/00
  5. A61K 31/155 + A61K 2300/00
  6. A61K 31/05 + A61K 2300/00

Citation (search report)

  • [Y] MICHAEL ZEMEL ET AL: "Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity", DIABETES, METABOLIC SYNDROME AND OBESITY: TARGETS AND THERAPY, February 2013 (2013-02-01), pages 93, XP055172148, ISSN: 1178-7007, DOI: 10.2147/DMSO.S40840
  • [Y] L PIZZORNO: "Resveratrol, Niacin, Nicotinamide Riboside: Key Players in Activating Sirtuins to Mimic Calorie Restriction & Extend Lifespan, Part I", LONGEVITY MEDICINE REVIEW, 2 October 2010 (2010-10-02), pages 1 - 15, XP055464992, Retrieved from the Internet <URL:https://web.archive.org/web/20101002061312/http://www.lmreview.com/articles/view/resveratrol-niacin-nicotinamide-riboside-key-players-in-activating-sirtuins-to-mimic-calorie-restriction-extend-lifespan-part-i/> [retrieved on 20180405]
  • [A] SOKRATES STEIN ET AL: "Protective roles of SIRT1 in atherosclerosis", CELL CYCLE, vol. 10, no. 4, 15 February 2011 (2011-02-15), US, pages 640 - 647, XP055464956, ISSN: 1538-4101, DOI: 10.4161/cc.10.4.14863
  • [T] ANTJE BRUCKBAUER ET AL: "Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice", AM J CARDIOVASC DIS, vol. 7, no. 2, 15 April 2017 (2017-04-15), pages 33 - 47, XP055464949
  • See also references of WO 2016049236A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2016049236 A1 20160331; EP 3197437 A1 20170802; EP 3197437 A4 20180523; US 2018235917 A1 20180823

DOCDB simple family (application)

US 2015051793 W 20150923; EP 15844508 A 20150923; US 201515513115 A 20150923