EP 3198035 B1 20221102 - METHODS FOR PREDICTING DRUG RESPONSIVENESS
Title (en)
METHODS FOR PREDICTING DRUG RESPONSIVENESS
Title (de)
VERFAHREN ZUR VORHERSAGE DES ANSPRECHENS AUF ARZNEIMITTEL
Title (fr)
PROCÉDÉS DE PRÉDICTION DE LA RÉACTIVITÉ À UN MÉDICAMENT
Publication
Application
Priority
- US 201462056295 P 20140926
- IB 2015002055 W 20150925
Abstract (en)
[origin: WO2016046640A2] The present invention provides drug response predictors and biomarkers useful for assessing the responsiveness of a subject to treatment with one or more target drugs of interest, such as 5-fluorouracil (5- FU), irinotecan, and/or oxaliplatin. In particular, the invention provides methods useful in determining whether a subject is sensitive or resistant to a target drug by, e.g., measuring the expression level of one or more biomarkers of sensitivity and/or resistance to the drug in a biological sample obtained from the subject. The invention further features devices and kits for assessing target drug responsiveness in a subject, for example, by determining the expression level of such biomarkers.
IPC 8 full level
C12Q 1/68 (2018.01)
CPC (source: EP US)
A61K 9/0019 (2013.01 - US); A61K 31/15 (2013.01 - EP US); A61K 31/436 (2013.01 - EP US); A61K 31/4745 (2013.01 - EP US); A61K 31/513 (2013.01 - EP US); A61K 31/519 (2013.01 - EP US); A61K 31/555 (2013.01 - EP US); A61K 38/14 (2013.01 - EP US); C12Q 1/6886 (2013.01 - EP US); C12Q 2600/106 (2013.01 - EP US); C12Q 2600/118 (2013.01 - US); C12Q 2600/158 (2013.01 - EP US)
Citation (examination)
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- WO 2012106718 A2 20120809 - BIOARRAY THERAPEUTICS INC [US], et al
- WO 2005100606 A2 20051027 - GENOMIC HEALTH INC [US], et al
- WO 2008073629 A2 20080619 - UNIV TEXAS [US], et al
- WO 2014195032 A1 20141211 - MEDICAL PROGNOSIS INST A S [DK]
- EP 2081950 A2 20090729 - NUCLEA BIOMARKERS LLC [US]
- US 2012046186 A1 20120223 - PELHAM ROBERT J [US], et al
- WO 2013130465 A2 20130906 - GENOMIC HEALTH INC [US]
- AKIO OOYAMA ET AL: "Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs", CANCER SCIENCE, vol. 97, no. 6, 1 June 2006 (2006-06-01), pages 510 - 522, XP055048094, ISSN: 1347-9032, DOI: 10.1111/j.1349-7006.2006.00204.x
- I K BUHL ET AL: "gastrointestinal tumours, colorectal 503PD A GENETIC RESPONSE PROFILE TO PREDICT EFFICACY OF ADJUVANT 5-FU IN COLON CANCER", ANNALS OF ONCOLOGY, vol. 25, no. supplement 4, 4 September 2014 (2014-09-04), pages 167 - 209, XP055253335, DOI: 10.1093/annonc/mdu333.6
- MIZUTANI ET AL: "Significance of Orotate Phosphoribosyltransferase Activity in Renal Cell Carcinoma", JOURNAL OF UROL, LIPPINCOTT WILLIAMS & WILKINS, BALTIMORE, MD, US, vol. 171, no. 2, 1 February 2004 (2004-02-01), pages 605 - 610, XP005532590, ISSN: 0022-5347, DOI: 10.1097/01.JU.0000107833.03488.D2
- OKUMURA K ET AL: "Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancer", ONCOLOGY REPORTS, NATIONAL HELLENIC RESEARCH FOUNDATION, vol. 15, no. 4, 15 April 2006 (2006-04-15), pages 875 - 882, XP002754884, ISSN: 1021-335X, [retrieved on 20060401], DOI: 10.3892/OR.15.4.875
- AKIO OOYAMA ET AL: "Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs", CANCER SCIENCE, vol. 97, no. 6, 1 June 2006 (2006-06-01), pages 510 - 522, XP055048094, ISSN: 1347-9032, DOI: 10.1111/j.1349-7006.2006.00204.x
- I K BUHL ET AL: "gastrointestinal tumours, colorectal 503PD A GENETIC RESPONSE PROFILE TO PREDICT EFFICACY OF ADJUVANT 5-FU IN COLON CANCER", ANNALS OF ONCOLOGY, vol. 25, no. supplement 4, 4 September 2014 (2014-09-04), pages 167 - 209, XP055253335, DOI: 10.1093/annonc/mdu333.6
- MIZUTANI ET AL: "Significance of Orotate Phosphoribosyltransferase Activity in Renal Cell Carcinoma", JOURNAL OF UROL, LIPPINCOTT WILLIAMS & WILKINS, BALTIMORE, MD, US, vol. 171, no. 2, 1 February 2004 (2004-02-01), pages 605 - 610, XP005532590, ISSN: 0022-5347, DOI: 10.1097/01.JU.0000107833.03488.D2
- OKUMURA K ET AL: "Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancer", ONCOLOGY REPORTS, NATIONAL HELLENIC RESEARCH FOUNDATION, vol. 15, no. 4, 15 April 2006 (2006-04-15), pages 875 - 882, XP002754884, ISSN: 1021-335X, [retrieved on 20060401], DOI: 10.3892/OR.15.4.875
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2016046640 A2 20160331; WO 2016046640 A3 20160804; DK 3198035 T3 20230130; EP 3198035 A2 20170802; EP 3198035 B1 20221102; FI 3198035 T3 20230131; US 10570457 B2 20200225; US 2017283884 A1 20171005
DOCDB simple family (application)
IB 2015002055 W 20150925; DK 15820250 T 20150925; EP 15820250 A 20150925; FI 15820250 T 20150925; US 201515509798 A 20150925