EP 3204000 B1 20200108 - PHENYLKETONE CARBOXYLATE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS
Title (en)
PHENYLKETONE CARBOXYLATE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS
Title (de)
PHENYLKETONCARBOXYLATVERBINDUNGEN UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN ZUR VORBEUGUNG UND BEHANDLUNG VON OSTEOPOROSE
Title (fr)
COMPOSÉS CARBOXYLATE DE PHÉNYLCÉTONE ET COMPOSITIONS PHARMACEUTIQUES DE PRÉVENTION ET DE TRAITEMENT DE L'OSTÉOPOROSE
Publication
Application
Priority
- US 201462062660 P 20141010
- CA 2015000530 W 20151008
Abstract (en)
[origin: WO2016054725A1] The present invention concerns the use of compounds for preventing and/or treating osteoporosis, for stimulating bone formation, for stimulating the differentiation and mineralization of osteoblasts, or for inhibiting bone resorption in a subject. These novel uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts thereof. wherein: R1and R2 are independently equal to H, F or OH; A is (CH2)mCOOH, W(CH2)mCOOH, or Y-CH(COOH)-(CH2)p-CH3 when B is H; or B is (CH2)mCOOH, W(CH2)mCOOH, or Y-CH(COOH)-(CH2)p-CH3 when A is H; or A and B are covalently bonded to form a five (5), six (6), or seven (7)-membered cycloalkyl substituted with COOH; where: Y is O, S, HN or CH2; W is 0, S or NH; m is 0-2; and p is 3-7; D is CO(CH2)nCH3 or CHOH(CH2)nCH3 or 0(CH2)nCH3 where n is 2-6; and E is H or F.
IPC 8 full level
A61K 31/20 (2006.01); A61K 31/192 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01)
CPC (source: EP IL KR RU US)
A61K 31/192 (2013.01 - EP IL KR RU US); A61K 31/196 (2013.01 - RU); A61K 31/20 (2013.01 - EP IL KR RU US); A61K 31/222 (2013.01 - RU); A61K 31/235 (2013.01 - RU); A61K 45/06 (2013.01 - IL KR); A61P 19/08 (2018.01 - EP US); A61P 19/10 (2018.01 - EP KR RU US); A61P 37/02 (2018.01 - RU); C07C 59/84 (2013.01 - IL KR); C07C 59/86 (2013.01 - IL KR); C07C 59/90 (2013.01 - IL KR); A61K 31/13 (2013.01 - US); A61K 31/275 (2013.01 - US); A61K 31/662 (2013.01 - US); A61K 38/16 (2013.01 - US); A61K 2300/00 (2013.01 - IL KR US)
C-Set (source: EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2016054725 A1 20160414; AR 102247 A1 20170215; AU 2015330642 A1 20170511; AU 2015330642 B2 20190704; BR 112017007386 A2 20180123; CA 2963358 A1 20160414; CA 2963358 C 20230307; CN 106999459 A 20170801; CN 106999459 B 20200710; DK 3204000 T3 20200406; EP 3204000 A1 20170816; EP 3204000 A4 20180620; EP 3204000 B1 20200108; ES 2794782 T3 20201119; IL 251409 A0 20170529; IL 251409 B 20200831; JP 2017530179 A 20171012; JP 6700638 B2 20200527; KR 20170066613 A 20170614; MX 2017004735 A 20171117; MY 187511 A 20210924; PH 12017500636 A1 20170925; PL 3204000 T3 20200727; PT 3204000 T 20200506; RU 2017116154 A 20181112; RU 2017116154 A3 20190506; RU 2712027 C2 20200127; SG 11201702810T A 20170530; TW 201618761 A 20160601; TW I723962 B 20210411; US 10925846 B2 20210223; US 2019038580 A1 20190207; UY 36355 A 20160601
DOCDB simple family (application)
CA 2015000530 W 20151008; AR P150103295 A 20151013; AU 2015330642 A 20151008; BR 112017007386 A 20151008; CA 2963358 A 20151008; CN 201580066144 A 20151008; DK 15849766 T 20151008; EP 15849766 A 20151008; ES 15849766 T 20151008; IL 25140917 A 20170327; JP 2017518894 A 20151008; KR 20177012549 A 20151008; MX 2017004735 A 20151008; MY PI2017000530 A 20151008; PH 12017500636 A 20170406; PL 15849766 T 20151008; PT 15849766 T 20151008; RU 2017116154 A 20151008; SG 11201702810T A 20151008; TW 104133246 A 20151008; US 201515516635 A 20151008; UY 36355 A 20151013