EP 3209128 A1 20170830 - NOVEL COMPOSITION AND SOLUTION WITH CONTROLLED CALCIUM ION LEVEL, AND RELATED METHOD AND USE FOR REPERFUSION
Title (en)
NOVEL COMPOSITION AND SOLUTION WITH CONTROLLED CALCIUM ION LEVEL, AND RELATED METHOD AND USE FOR REPERFUSION
Title (de)
NEUARTIGE ZUSAMMENSETZUNG UND LÖSUNG MIT KONTROLLIERTEM CALCIUMIONENGEHALT UND ZUGEHÖRIGES VERFAHREN UND VERWENDUNG ZUR REPERFUSION
Title (fr)
NOUVELLE COMPOSITION ET SOLUTION AYANT UN NIVEAU D'IONS CALCIUM CONTRÔLÉ, PROCÉDÉ ASSOCIÉ ET SON UTILISATION EN REPERFUSION
Publication
Application
Priority
- US 201462068524 P 20141024
- CA 2015050297 W 20150410
- CA 2015051084 W 20151023
Abstract (en)
[origin: WO2016061700A1] A solution comprises a preservation mixture comprising a calcium ion source; and a buffer for maintaining a pH of the solution. The molar concentration of calcium ion (Ca2+) in the solution is from 0.18 to 0.26 mmol/L, and the pH is lower than 7.4 and higher than 6.6. A composition for preparing the solution may comprise adenosine, lidocaine, and a calcium source, wherein the molar ratio of adenosine:calcium is from 0.3:0.26 to 0.45:0.18, and the molar ratio of lidocaine:calcium is from 0.04:0.26 to 0.09:0.18. A donor heart may be reperfused with the solution. The solution may be used for reperfusion of a donor heart, such as at a temperature from about 25 to about 37 °C. The donor may be a donor after circulatory death.
IPC 8 full level
A01N 1/02 (2006.01)
CPC (source: EP US)
A01N 1/0226 (2013.01 - EP US); A61K 31/167 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2016061700 A1 20160428; AU 2015336862 A1 20170601; AU 2015336862 B2 20180809; BR 112017008076 A2 20171226; BR 112017008076 B1 20210629; CA 2965400 A1 20160428; CA 2965400 C 20230314; CN 107105640 A 20170829; CN 107105640 B 20211012; CN 113841687 A 20211228; EP 3209128 A1 20170830; EP 3209128 A4 20180411
DOCDB simple family (application)
CA 2015051084 W 20151023; AU 2015336862 A 20151023; BR 112017008076 A 20151023; CA 2965400 A 20151023; CN 201580070774 A 20151023; CN 202111194944 A 20151023; EP 15853016 A 20151023