Global Patent Index - EP 3209128 A4

EP 3209128 A4 20180411 - NOVEL COMPOSITION AND SOLUTION WITH CONTROLLED CALCIUM ION LEVEL, AND RELATED METHOD AND USE FOR REPERFUSION

Title (en)

NOVEL COMPOSITION AND SOLUTION WITH CONTROLLED CALCIUM ION LEVEL, AND RELATED METHOD AND USE FOR REPERFUSION

Title (de)

NEUARTIGE ZUSAMMENSETZUNG UND LÖSUNG MIT KONTROLLIERTEM CALCIUMIONENGEHALT UND ZUGEHÖRIGES VERFAHREN UND VERWENDUNG ZUR REPERFUSION

Title (fr)

NOUVELLE COMPOSITION ET SOLUTION AYANT UN NIVEAU D'IONS CALCIUM CONTRÔLÉ, PROCÉDÉ ASSOCIÉ ET SON UTILISATION EN REPERFUSION

Publication

EP 3209128 A4 20180411 (EN)

Application

EP 15853016 A 20151023

Priority

  • US 201462068524 P 20141024
  • CA 2015050297 W 20150410
  • CA 2015051084 W 20151023

Abstract (en)

[origin: WO2016061700A1] A solution comprises a preservation mixture comprising a calcium ion source; and a buffer for maintaining a pH of the solution. The molar concentration of calcium ion (Ca2+) in the solution is from 0.18 to 0.26 mmol/L, and the pH is lower than 7.4 and higher than 6.6. A composition for preparing the solution may comprise adenosine, lidocaine, and a calcium source, wherein the molar ratio of adenosine:calcium is from 0.3:0.26 to 0.45:0.18, and the molar ratio of lidocaine:calcium is from 0.04:0.26 to 0.09:0.18. A donor heart may be reperfused with the solution. The solution may be used for reperfusion of a donor heart, such as at a temperature from about 25 to about 37 °C. The donor may be a donor after circulatory death.

IPC 8 full level

A01N 1/02 (2006.01)

CPC (source: EP US)

A01N 1/0226 (2013.01 - EP US); A61K 31/167 (2013.01 - EP US)

Citation (search report)

  • [A] US 5407793 A 19950418 - DEL NIDO PEDRO J [US], et al
  • [Y] US 2005202394 A1 20050915 - DOBSON GEOFFREY P [AU]
  • [A] US 2003124503 A1 20030703 - OLIVENCIA-YURVATI ALBERT H [US], et al
  • [Y] WO 0101774 A1 20010111 - UNIV CALIFORNIA [US], et al
  • [Y] DOBSON G P ET AL: "Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURG, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 127, no. 3, 1 March 2004 (2004-03-01), pages 794 - 805, XP008092313, ISSN: 0022-5223, DOI: 10.1016/S0022-5223(03)01192-9
  • [Y] DONNA M RUDD ET AL: "Eight hours of cold static storage with adenosine and lidocaine (Adenocaine) heart preservation solutions: Toward therapeutic suspended animation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 142, no. 6, 5 May 2011 (2011-05-05), pages 1552 - 1561, XP028111611, ISSN: 0022-5223, [retrieved on 20110528], DOI: 10.1016/J.JTCVS.2011.05.023
  • [Y] STACY B O BLENES ET AL: "Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 141, no. 3, 2 June 2010 (2010-06-02), pages 762 - 770, XP028144755, ISSN: 0022-5223, [retrieved on 20100607], DOI: 10.1016/J.JTCVS.2010.06.004
  • [Y] N TAKEMOTO, H KURODA, T MORI: "THE RECIPROCAL PROTECTIVE EFFECTS OF MAGNESIUM AND CALCIUM IN HYPERKALEMIC CARDIOPLEGIC SOLUTIONS ON ISCHEMIC MYOCARDIUM", BASIC RESEARCH IN CARDIOLOGY, vol. 87, 1 September 1992 (1992-09-01), pages 559 - 569, XP009503749
  • [Y] D J HEARSE ET AL: "Protection of the myocardium during ischemic arrest. Dose response curves for procaine and lignocaine in cardioplegic solutions", MEDLINE, 1 June 1981 (1981-06-01), U.S.A., pages 1 - 2, XP055454788, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pubmed/7230856> [retrieved on 20180227]
  • See references of WO 2016061700A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2016061700 A1 20160428; AU 2015336862 A1 20170601; AU 2015336862 B2 20180809; BR 112017008076 A2 20171226; BR 112017008076 B1 20210629; CA 2965400 A1 20160428; CA 2965400 C 20230314; CN 107105640 A 20170829; CN 107105640 B 20211012; CN 113841687 A 20211228; EP 3209128 A1 20170830; EP 3209128 A4 20180411

DOCDB simple family (application)

CA 2015051084 W 20151023; AU 2015336862 A 20151023; BR 112017008076 A 20151023; CA 2965400 A 20151023; CN 201580070774 A 20151023; CN 202111194944 A 20151023; EP 15853016 A 20151023