EP 3212773 A4 20180620 - EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR
Title (en)
EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR
Title (de)
EFFIZIENTE ABGABE VON THERAPEUTISCHEN MOLEKÜLEN AN ZELLEN DES INNENOHRES
Title (fr)
ADMINISTRATION EFFICACE DE MOLÉCULES THÉRAPEUTIQUES EN DIRECTION DE CELLULES DE L'OREILLE INTERNE
Publication
Application
Priority
- US 201462072220 P 20141029
- US 2015058081 W 20151029
Abstract (en)
[origin: WO2016069906A1] Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.
IPC 8 full level
A61K 38/17 (2006.01); A61P 27/16 (2006.01); C07H 21/04 (2006.01); C12N 5/0793 (2010.01); C12N 15/87 (2006.01)
CPC (source: EP US)
A61K 9/0046 (2013.01 - EP US); A61K 9/5068 (2013.01 - EP US); A61P 27/16 (2017.12 - EP US); C07K 14/43595 (2013.01 - US); C07K 14/463 (2013.01 - US); C07K 14/47 (2013.01 - US); C07K 14/705 (2013.01 - US); C12N 5/062 (2013.01 - EP US); C12N 5/0627 (2013.01 - US); A61K 38/00 (2013.01 - EP US); C07K 2319/00 (2013.01 - US); C12N 2501/42 (2013.01 - EP US); C12N 2501/60 (2013.01 - EP US); C12N 2501/606 (2013.01 - EP US); C12N 2501/998 (2013.01 - US); C12N 2506/00 (2013.01 - US)
Citation (search report)
- [IP] MARGIE LI ET AL: "Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 137, no. 44, 14 October 2015 (2015-10-14), pages 14084 - 14093, XP055469154, ISSN: 0002-7863, DOI: 10.1021/jacs.5b05694
- [Y] JOSEPH C. BURNS ET AL: "MYC Gene Delivery to Adult Mouse Utricles Stimulates Proliferation of Postmitotic Supporting Cells In Vitro", PLOS ONE, vol. 7, no. 10, 30 October 2012 (2012-10-30), pages e48704, XP055472838, DOI: 10.1371/journal.pone.0048704
- [Y] SHANNON KRAFT ET AL: "Atoh1 induces auditory hair cell recovery in mice after ototoxic injury", THE LARYNGOSCOPE, vol. 123, no. 4, 11 March 2013 (2013-03-11), United States, pages 992 - 999, XP055277861, ISSN: 0023-852X, DOI: 10.1002/lary.22171
- [Y] "Protein Engineering for Therapeutics, Part B", vol. 503, 1 January 2012, ELSEVIER, ISBN: 978-0-12-396962-0, ISSN: 0076-6879, article DAVID B. THOMPSON ET AL: "Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells", pages: 293 - 319, XP055044980, DOI: 10.1016/B978-0-12-396962-0.00012-4
- [T] KARAGIANNIS E D ET AL: "Rational design of a biomimetic cell penetrating peptide library", ACS NANO 20131022 AMERICAN CHEMICAL SOCIETY USA,, vol. 7, no. 10, 22 October 2013 (2013-10-22), pages 8616 - 8626, XP002770871, DOI: 10.1021/NN4027382
- See references of WO 2016069906A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2016069906 A1 20160506; EP 3212773 A1 20170906; EP 3212773 A4 20180620; EP 3212773 B1 20210915; US 11370823 B2 20220628; US 2017327557 A1 20171116; US 2022281941 A1 20220908
DOCDB simple family (application)
US 2015058081 W 20151029; EP 15855303 A 20151029; US 201515523317 A 20151029; US 202217750530 A 20220523