EP 3215186 A2 20170913 - COMPOSITIONS AND METHODS FOR TREATING HIF-1alpha OVER-EXPRESSING CANCERS
Title (en)
COMPOSITIONS AND METHODS FOR TREATING HIF-1alpha OVER-EXPRESSING CANCERS
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON HIF-1 ALPHA-ÜBEREXPRIMIERENDEN KARZINOMEN
Title (fr)
COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE CANCERS SUREXPRIMANT HIF-1ALPHA
Publication
Application
Priority
- US 201462075129 P 20141104
- US 2015059104 W 20151104
Abstract (en)
[origin: WO2016073647A2] Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90α and methods of using the same to treat HIF-1a-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP in Hsp90α or VKHFSVEGQ in Hsp90α
IPC 8 full level
A61K 39/00 (2006.01)
CPC (source: EP)
A61K 31/713 (2013.01); C07K 16/18 (2013.01); C12N 15/113 (2013.01); C07K 2317/34 (2013.01); C07K 2317/76 (2013.01); C12N 2310/10 (2013.01); C12N 2310/20 (2017.04)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2016073647 A2 20160512; WO 2016073647 A3 20160825; CN 107106669 A 20170829; EP 3215186 A2 20170913; EP 3215186 A4 20181024
DOCDB simple family (application)
US 2015059104 W 20151104; CN 201580067543 A 20151104; EP 15856516 A 20151104