EP 3216805 A1 20170913 - ANTIBODIES THAT INHIBIT METALLOPROTEINS

Title (en)

ANTIBODIES THAT INHIBIT METALLOPROTEINS

Title (de)

ANTIKÖRPER ZUR HEMMUNG VON METALLOPROTEINEN

Title (fr)

ANTICORPS INHIBANT LES MÉTALLOPROTÉINES

Publication

EP 3216805 A1 20170913 (EN)

Application

EP 16198239 A 20110127

Previously filed application

PCT/IL2011/000098 20110127 WO

Priority

US 29860310 P 20100127
US 39173010 P 20101011
EP 11705282 A 20110127

Abstract (en)

The present invention relates to an antibody which inhibits the catalytic activity of MMP-9 and MMP-2 comprising an antigen recognition region which comprises the six CDR amino acid sequences as set forth in SEQ ID NOs: 4, 5, 6, 7, 8 and 9.

IPC 8 full level

C07K 16/44 (2006.01)

CPC (source: EP US)

A61P 1/00 (2017.12 - EP); A61P 25/28 (2017.12 - EP); C07K 16/40 (2013.01 - EP US); C07K 16/44 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/55 (2013.01 - EP US); C07K 2317/76 (2013.01 - EP US); C07K 2317/92 (2013.01 - EP US)

Citation (applicant)

WO 2004087042 A2 20041014 - YEDA RES & DEV [IL], et al
WO 2008102359 A1 20080828 - YEDA RES & DEV [IL], et al
US 5189178 A 19930223 - GALARDY RICHARD E [US], et al
US 5239078 A 19930824 - GALARDY RICHARD E [US], et al
US 4036945 A 19770719 - HABER EDGAR
US 4331647 A 19820525 - GOLDENBERG MILTON D
US 4946778 A 19900807 - LADNER ROBERT C [US], et al
US 4816567 A 19890328 - CABILLY SHMUEL [US], et al
US 5545807 A 19960813 - SURANI AZIM M [GB], et al
US 5545806 A 19960813 - LONBERG NILS [US], et al
US 5569825 A 19961029 - LONBERG NILS [US], et al
US 5625126 A 19970429 - LONBERG NILS [US], et al
US 5633425 A 19970527 - LONBERG NILS [US], et al
US 5661016 A 19970826 - LONBERG NILS [US], et al
US 4743587 A 19880510 - DICKENS JONATHAN P [GB], et al
US 5240958 A 19930831 - CAMPION COLIN [GB], et al
US 6037137 A 20000314 - KOMORIYA AKIRA [US], et al
US 6350466 B1 20020226 - LI KING CHUEN [US], et al
US 3940475 A 19760224 - GROSS STANLEY JOSEPH
US 4289747 A 19810915 - CHU ALBERT E
US 4376110 A 19830308 - DAVID GARY S, et al
US 5800814 A 19980901 - FUSEK MARTIN [US], et al
US 4873316 A 19891010 - MEADE HARRY [US], et al
EP 0264166 A1 19880420 - INTEGRATED GENETICS INC [US]
US 3817837 A 19740618 - RUBENSTEIN K, et al
US 3850752 A 19741126 - SCHUURS A, et al
US 3939350 A 19760217 - KRONICK MELVYN N, et al
US 3996345 A 19761207 - ULLMAN EDWIN F, et al
US 4277437 A 19810707 - MAGGIO EDWARD T
US 4275149 A 19810623 - LITMAN DAVID J, et al
US 4366241 A 19821228 - TOM HENRY K, et al
US 4666828 A 19870519 - GUSELLA JAMES F [US]
US 4683202 A 19870728 - MULLIS KARY B [US]
US 4801531 A 19890131 - FROSSARD PHILIPPE M [US]
US 5192659 A 19930309 - SIMONS MALCOLM J [AU]
US 5272057 A 19931221 - SMULSON MARK E [US], et al
US 3791932 A 19740212 - SCHUURS A, et al
US 3839153 A 19741001 - SCHUURS A, et al
US 3850578 A 19741126 - MCCONNELL H
US 3853987 A 19741210 - DREYER W
US 3867517 A 19750218 - LING CHUNG-MEI
US 3879262 A 19750422 - SCHUURS ANTONIUS HERMANUS WILH, et al
US 3901654 A 19750826 - GROSS STANLEY J
US 3935074 A 19760127 - RUBENSTEIN KENNETH EDWARD, et al
US 3984533 A 19761005 - UZGIRIS EGIDIJUS E
US 4034074 A 19770705 - MILES LAUGHTON E M
US 4098876 A 19780704 - PIASIO ROGER N, et al
US 4879219 A 19891107 - WANDS JACK R [US], et al
US 5011771 A 19910430 - BELLET DOMINIQUE [FR], et al
US 5281521 A 19940125 - TROJANOWSKI JOHN Q [US], et al
BRAIN RES., 2007
ORLANDI D.R. ET AL., PROC. NATL. ACAD. SCI., vol. 86, 1989, pages 3833 - 3837
WINTER G. ET AL., NATURE, vol. 349, 1991, pages 293 - 299
KOHLER G. ET AL., NATURE, vol. 256, 1975, pages 495 - 497
KOZBOR D. ET AL., J. IMMUNOL. METHODS, vol. 81, 1985, pages 31 - 42
COTE R.J. ET AL., PROC. NATL. ACAD. SCI., vol. 80, 1983, pages 2026 - 2030
COLE S.P. ET AL., MOL. CELL. BIOL., vol. 62, 1984, pages 109 - 120
HARLOW; LANE: "Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
PORTER, R. R., BIOCHEM. J., vol. 73, 1959, pages 119 - 126
INBAR ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 69, 1972, pages 2659 - 2662
WHITLOW; FILPULA, METHODS, vol. 2, 1991, pages 97 - 105
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
PACK ET AL., BIO/TECHNOLOGY, vol. 11, 1993, pages 1271 - 1277
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
VERHOEYEN ET AL., SCIENCE, vol. 239, 1988, pages 1534 - 1536
HOOGENBOOM; WINTER, J. MOL. BIOL., vol. 227, 1991, pages 381
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581
COLE ET AL.: "Monoclonal Antibodies and Cancer Therapy", 1985, ALAN R. LISS, pages: 77
BOERNER ET AL., J. IMMUNOL., vol. 147, no. 1, 1991, pages 86 - 95
MARKS ET AL., BIO/TECHNOLOGY, vol. 10, 1992, pages 779 - 783
LONBERG ET AL., NATURE, vol. 368, 1994, pages 856 - 859
MORRISON, NATURE, vol. 368, 1994, pages 812 - 813
FISHWILD ET AL., NATURE BIOTECHNOLOGY, vol. 14, 1996, pages 845 - 851
NEUBERGER, NATURE BIOTECHNOLOGY, vol. 14, 1996, pages 826
LONBERG; HUSZAR, INTERN. REV. IMMUNOL., vol. 13, 1995, pages 65 - 93
KNIGHT ET AL., FEBS LETTERS, vol. 296, no. 3, 1992, pages 263 - 266
CAWSTON ET AL., ANAL. BIOCHEM, vol. 99, 1979, pages 340 - 345
CAWSTON ET AL., METHODS IN ENZYMOLOGY, vol. 80, 1981, pages 771
CAWSTON ET AL., BIOCHEM. J., vol. 195, 1981, pages 159 - 165
WEINGARTEN ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 139, 1984, pages 1184 - 1187
VAN WART; BIRKEDAL-HANSEN, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 5578 - 5582
F. CHOPLIN: "Quantitative Drug Design", 1992, PERGAMON PRESS
STEWART, J. M.; YOUNG, J. D.: "Solid Phase Peptide Synthesis", 1963, W. H. FREEMAN CO.
MEIENHOFER, J: "Hormonal Proteins and Peptides", vol. 2, 1973, ACADEMIC PRESS, pages: 46
SCHRODER, G.; LUPKE, K.: "The Peptides", vol. 1, 1965, ACADEMIC PRESS
KHATKHATAY MI.; DESAI M., J IMMUNOASSAY, vol. 20, 1999, pages 151 - 183
WISDOM GB, METHODS MOL BIOL., vol. 32, 1994, pages 433 - 440
ISHIKAWA E. ET AL., J IMMUNOASSAY, vol. 4, 1983, pages 209 - 327
OELLERICH M., J CLIN CHEM CLIN BIOCHEM., vol. 18, 1980, pages 197 - 208
SCHUURS AH.; VAN WEEMEN BK., J IMMUNOASSAY, vol. 1, 1980, pages 229 - 249
DENKBERG, G. ET AL., EUR. J. IMMUNOL., vol. 30, 2000, pages 3522 - 3532
CLOUTIER SM. ET AL., MOLECULAR IMMUNOLOGY, vol. 37, 2000, pages 1067 - 1077
DUBEL S. ET AL., J IMMUNOL METHODS, vol. 178, 1995, pages 201
HUSTON JS. ET AL., METHODS IN ENZYMOLOGY, vol. 203, 1991, pages 46
KIPRIYANOV SM. ET AL., HUM ANTIBODIES HYBRIDOMAS, vol. 6, 1995, pages 93
KIPRIYANOV SM., PROTEIN ENGINEERING, vol. 9, 1996, pages 203
PEARCE LA. ET AL., BIOCHEM MOLEC BIOL INTL, vol. 42, 1997, pages 1179 - 1188
CUMBER ET AL., METHODS OF ENZYMOLOGY, vol. 112, 1985, pages 207 - 224
G.T. HERMANSON: "Antibody Modification and Conjugation, in Bioconjugate Techniques", 1996, ACADEMIC PRESS
J. MARCH: "Advanced Organic Chemistry: Reaction's, Mechanism, and Structure", 1985, pages: 349 - 50,372-7
B. NEISES ET AL., ANGEW CHEM., INT. ED. ENGL., vol. 17, 1978, pages 522
A. HASSNER ET AL., TETRAHEDRON LETT., 1978, pages 4475
E.P. BODEN ET AL., J. ORG. CHEM., vol. 50, 1986, pages 2394
L.J. MATHIAS, SYNTHESIS, 1979, pages 561
"Remington's Pharmaceutical Sciences", MACK PUBLISHING CO.
FINGL ET AL.: "The Pharmacological Basis of Therapeutics", 1975, article "Ch. 1", pages: L
HUSTON ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
DE KRUIF ET AL., J. MOL. BIOL., vol. 248, 1995, pages 97 - 105
PINKERT ET AL., GENES DEV., vol. 1, 1987, pages 268 - 277
CALAME ET AL., ADV. IMMUNOL., vol. 43, 1988, pages 235 - 275
WINOTO ET AL., EMBO J., vol. 8, 1989, pages 729 - 733
BANERJI ET AL., CELL, vol. 33, 1983, pages 729 - 740
BYME ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 5473 - 5477
EDLUNCH ET AL., SCIENCE, vol. 230, 1985, pages 912 - 916
TONKINSON ET AL., CANCER INVESTIGATION, vol. 14, no. 1, 1996, pages 54 - 65
SOMIA; VERMA, NATURE REVIEWS, vol. 1, 2000, pages 91 - 99
ISNER, MYOCARDIAL GENE THERAPY. NATURE, vol. 415, 2002, pages 234 - 239
HIGH: "Gene therapy: a 2001 perspective", HAEMOPHILIA, vol. 7, 2001, pages 23 - 27
HAMMOND; MCKIRNAN, ANGIOGENIC GENE THERAPY FOR HEART DISEASE: A REVIEW OF ANIMAL STUDIES AND CLINICAL TRIALS, vol. 49, 2001, pages 561 - 567
SAMBROOK ET AL.: "Molecular Cloning: A laboratory Manual", 1989
"Current Protocols in Molecular Biology", vol. I-III, 1994
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1989, JOHN WILEY AND SONS
PERBAL: "A Practical Guide to Molecular Cloning", 1988, JOHN WILEY & SONS
WATSON ET AL.: "Recombinant DNA", SCIENTIFIC AMERICAN BOOKS
"Genome Analysis: A Laboratory Manual Series", vol. 1-4, 1998, COLD SPRING HARBOR LABORATORY PRESS
"Cell Biology: A Laboratory Handbook", vol. I-III, 1994
FRESHNEY: "Culture of Animal Cells - A Manual of Basic Technique", 1994, WILEY-LISS
"Current Protocols in Immunology", vol. I-III, 1994
"Basic and Clinical Immunology", 1994, APPLETON & LANGE
MISHELL AND SHIIGI: "Selected Methods in Cellular Immunology", 1980, W. H. FREEMAN AND CO.
GAIT, M. J.: "Oligonucleotide Synthesis", 1984
HAMES, B. D., AND HIGGINS S. J.: "Nucleic Acid Hybridization", 1985
HAMES, B. D., AND HIGGINS S. J.: "Transcription and Translation", 1984
FRESHNEY, R. I.: "Animal Cell Culture", 1986
"Immobilized Cells and Enzymes", 1986, IRL PRESS
PERBAL, B.: "A Practical Guide to Molecular Cloning", 1984
"Methods in Enzymology", vol. 1-317, ACADEMIC PRESS
"PCR Protocols: A Guide To Methods And Applications", 1990, ACADEMIC PRESS
MARSHAK ET AL.: "Strategies for Protein Purification and Characterization - A Laboratory Course Manual", 1996, CSHL PRESS
R. FRIDMAN ET AL., J BIOL CHEM, vol. 267, 5 August 1992 (1992-08-05), pages 15398
R. FRIDMAN ET AL, CANCER RES, vol. 55, 15 June 1995 (1995-06-15), pages 2548
M. L. MOSS ET AL., NATURE, vol. 385, 20 February 1997 (1997-02-20), pages 733
M. E. MILLA ET AL., J BIOL CHEM, vol. 274, 22 October 1999 (1999-10-22), pages 30563
I. H. SEGEL: "Enzyme Kinetics", 1993, WILEY-INTERSCIENCE PUBLICATION
REUTER ET AL., J CLIN INVEST, vol. 98, 1 November 1996 (1996-11-01), pages 2076
B. RAVEL; M. NEWVILLE, J SYNCHROTRON RADIAT, vol. 12, July 2005 (2005-07-01), pages 537
Z. OTWINOWSKI ET AL: "Methods in Enzymology", vol. 276, 1997, ACADEMIC PRESS, pages: 307 - 326
N. KOWALSMAN; M. EISENSTEIN, BIOINFORMATICS, vol. 23, 15 February 2007 (2007-02-15), pages 421
A. HEIFETZ; M. EISENSTEIN, PROTEIN ENG, vol. 16, March 2003 (2003-03-01), pages 179
E. KATCHALSKI-KATZIR ET AL., PROC NATL ACAD SCI U S A, vol. 89, 15 March 1992 (1992-03-15), pages 2195
M. EISENSTEIN ET AL, J MOL BIOL, vol. 266, 14 February 1997 (1997-02-14), pages 135
A. HEIFETZ ET AL, PROTEIN SCI, vol. 11, March 2002 (2002-03-01), pages 571
C. G. KNIGHT ET AL, FEBS LETT, vol. 296, 27 January 1992 (1992-01-27), pages 263
G. MONTELEONE ET AL, CURR OPIN GASTROENTEROL, vol. 22, July 2006 (2006-07-01), pages 361
P. GARG ET AL., AM J PHYSIOL GASTROINTEST LIVER PHYSIOL, vol. 296, February 2009 (2009-02-01), pages G175
A. P. SYKES ET AL., ALIMENT PHARMACOL THER, vol. 13, November 1999 (1999-11-01), pages 1535
P. DI SEBASTIANO ET AL., DIGESTION, vol. 63, 2001, pages 234
P. GARG ET AL., J IMMUNOL, vol. 177, 15 September 2006 (2006-09-15), pages 4103
N. R. WHITELEGG; A. R. REES, PROTEIN ENG, vol. 13, December 2000 (2000-12-01), pages 819
C. CHOTHIA ET AL., NATURE, vol. 342, 21 December 1989 (1989-12-21), pages 877
C. J. FARADY ET AL, J MOL BIOL, vol. 380, 4 July 2008 (2008-07-04), pages 351
Y. WU ET AL., PROC NATL ACAD SCI USA, vol. 104, 11 December 2007 (2007-12-11), pages 19784
WIRTZ ET AL., NAT PROTOC, vol. 2, 2007, pages 541 - 546
REUTER ET AL., J CLIN INVEST, vol. 98, 1996, pages 2076 - 2085
ELSON ET AL., J IMMUNOL, vol. 157, 1996, pages 2174 - 2185

Citation (search report)

[I] WO 2008102359 A1 20080828 - YEDA RES & DEV [IL], et al
[A] WO 2004087042 A2 20041014 - YEDA RES & DEV [IL], et al
[A] NAITO Y ET AL: "Role of matrix metalloproteinases in inflammatory bowel disease", MOLECULAR ASPECTS OF MEDICINE, PERGAMON PRESS, OXFORD, GB, vol. 26, no. 4-5, 1 August 2005 (2005-08-01), pages 379 - 390, XP025272593, ISSN: 0098-2997, [retrieved on 20050801], DOI: 10.1016/J.MAM.2005.07.009
[A] YONG ET AL: "Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators", JOURNAL OF NEUROLOGICAL SCIENCES, ELSEVIER SCIENTIFIC PUBLISHING CO, AMSTERDAM, NL, vol. 259, no. 1-2, 19 July 2007 (2007-07-19), pages 79 - 84, XP022149387, ISSN: 0022-510X, DOI: 10.1016/J.JNS.2006.11.021
[A] ANTHONY D C ET AL: "DIFFERENTIAL MATRIX METALLOPROTEINASE EXPRESSION IN CASES OF MULTIPLE SCLEROSIS AND STROKE", NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, LONDON, GB, vol. 23, 1 October 1997 (1997-10-01), pages 406 - 415, XP001057980, ISSN: 0305-1846, DOI: 10.1046/J.1365-2990.1997.00066.X
[A] LIEDTKE W ET AL: "EFFECTIVE TREATMENT OF MODELS OF MULTIPLE SCLEROSIS BY MATRIX METALLOPROTEINASE INHIBITORS", ANNALS OF NEUROLOGY, JOHN WILEY AND SONS, BOSTON, US, vol. 44, no. 1, 1 July 1998 (1998-07-01), pages 35 - 46, XP009070623, ISSN: 0364-5134, DOI: 10.1002/ANA.410440110
[A] SELA-PASSWELL NETTA ET AL: "Structural and functional bases for allosteric control of MMP activities: can it pave the path for selective inhibition?", BIOCHIMICA ET BIOPHYSICA ACTA JAN 2010 LNKD- PUBMED:19406173, vol. 1803, no. 1, January 2010 (2010-01-01), pages 29 - 38, XP002633534, ISSN: 0006-3002
[A] R. Z. CER ET AL: "IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding", NUCLEIC ACIDS RESEARCH, vol. 37, no. Web Server, 1 July 2009 (2009-07-01), pages W441 - W445, XP055168549, ISSN: 0305-1048, DOI: 10.1093/nar/gkp253

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2011092700 A1 20110804; AU 2011210362 A1 20120809; AU 2011210362 B2 20150910; CA 2787311 A1 20110804; CA 2787311 C 20170815; CN 102822202 A 20121212; CN 102822202 B 20150722; EA 201270701 A1 20130130; EP 2528949 A1 20121205; EP 3216805 A1 20170913; US 2013039922 A1 20130214; US 2014141014 A1 20140522; US 8697078 B2 20140415; US 9217041 B2 20151222

DOCDB simple family (application)

IL 2011000098 W 20110127; AU 2011210362 A 20110127; CA 2787311 A 20110127; CN 201180015001 A 20110127; EA 201270701 A 20110127; EP 11705282 A 20110127; EP 16198239 A 20110127; US 201113521452 A 20110127; US 201414168024 A 20140130