EP 3218370 A4 20180822 - METHODS AND COMPOSITIONS FOR INHIBITION OF BROMODOMAIN AND EXTRATERMINAL PROTEINS
Title (en)
METHODS AND COMPOSITIONS FOR INHIBITION OF BROMODOMAIN AND EXTRATERMINAL PROTEINS
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR HEMMUNG VON BROMODOMÄNEN- UND EXTRATERMINALEN PROTEINEN
Title (fr)
PROCÉDÉS ET COMPOSITIONS POUR L'INHIBITION DE PROTÉINES EXTRATERMINALES ET À BROMODOMAINE
Publication
Application
Priority
- US 201462079005 P 20141113
- US 2015060494 W 20151113
Abstract (en)
[origin: WO2016077656A2] The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.
IPC 8 full level
C07D 413/04 (2006.01); A61K 31/422 (2006.01); A61K 31/4725 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); C07D 215/227 (2006.01); C07D 215/40 (2006.01); C07D 401/04 (2006.01); C07D 413/14 (2006.01)
CPC (source: CN EP KR US)
A61K 31/4725 (2013.01 - KR); A61P 19/02 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 215/42 (2013.01 - CN EP KR US); C07D 401/04 (2013.01 - CN EP KR US); C07D 403/14 (2013.01 - KR); C07D 413/04 (2013.01 - CN EP KR US); C07D 413/14 (2013.01 - CN EP US)
Citation (search report)
- [A] WO 2014159837 A1 20141002 - CONVERGENE LLC [US], et al
- [X] WO 9217452 A1 19921015 - KOREA RES INST CHEM TECH [KR]
- [X] TIWARI ET AL: "Synthesis of new pyrazolidine 3,5 dione derivatives of potential analgesic, antipyretic and anti-inflammatory activities", MIDDLE EAST JOURNAL OF SCIENTIFIC RESEARCH, INTERNATIONAL DIGITAL ORGANIZATION FOR SCIENTIFIC INFORMATION (I D O S I), AE, vol. 17, no. 7, 1 January 2013 (2013-01-01), pages 926 - 35, XP009502881, ISSN: 1990-9233
- [X] ABHISHEK TIWARI ET AL: "Synthesis and evaluation of possible mechanism of anti nociceptive potential of novel 2-quinolone fused 3,5-pyrazolidinedione derivatives in experimental animal models", ANALELE UNIVERSITATII "OVIDIUS" CONSTANTA - SERIA CHIMIE, vol. 24, no. 1, 1 January 2013 (2013-01-01), XP055455458, ISSN: 1223-7221, DOI: 10.2478/auoc-2013-0001
- [X] ABASS M: "CHEMISTRY OF SUBSTITUTED QUINOLINONES. PART II SYNTHESIS OF NOVEL 4-PYRAZOLYLQUINOLINONE DERIVATIVES", SYNTHETIC COMMUNICAT, vol. 30, no. 15, 1 January 2000 (2000-01-01), TAYLOR & FRANCIS INC, PHILADELPHIA, PA; US, pages 2735 - 2757, XP008001993, ISSN: 0039-7911, DOI: 10.1080/00397910008086898
- [X] ABHISHEK TIWARI: "Synthesis and Biological Activity of Quinolone Derivatives", JOURNAL OF PHARMACY RESEARCH, vol. 4, no. 4, 4 April 2011 (2011-04-04), pages 1063 - 1064, XP009503796
- [X] PATEI V B ET AL: "2-Azetidinone. Part I. N-methyl-4-(4'-aryl-3'-chloro-2'-azetidinon-1-yl- amino)-2-(1H)-quinolone", JOURNAL OF THE INSTITUTION OF CHEMISTS, vol. 69, no. 1, 1 January 1997 (1997-01-01), (INDIA), INSTITUTION OF CHEMISTS, CALCUTTA, IN, pages 9 - 11, XP009503795, ISSN: 0020-3254
- See references of WO 2016077656A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2016077656 A2 20160519; WO 2016077656 A3 20160825; AU 2015346223 A1 20170608; CA 2966908 A1 20160519; CN 107207486 A 20170926; EP 3218370 A2 20170920; EP 3218370 A4 20180822; JP 2017534653 A 20171124; KR 20170118688 A 20171025; US 2019092761 A1 20190328
DOCDB simple family (application)
US 2015060494 W 20151113; AU 2015346223 A 20151113; CA 2966908 A 20151113; CN 201580061689 A 20151113; EP 15859533 A 20151113; JP 2017525549 A 20151113; KR 20177016118 A 20151113; US 201515526609 A 20151113