EP 3244968 A4 20180912 - COMBINATION THERAPY FOR PULMONARY HYPERTENSION
Title (en)
COMBINATION THERAPY FOR PULMONARY HYPERTENSION
Title (de)
KOMBINATIONSTHERAPIE FÜR PULMONALE HYPERTONIE
Title (fr)
TRAITEMENT COMBINÉ POUR L'HYPERTENSION PULMONAIRE
Publication
Application
Priority
- US 201562103020 P 20150113
- US 2016012694 W 20160108
Abstract (en)
[origin: WO2016114993A1] The present invention provides compositions and methods for the treatment of pulmonary hypertension using combination therapy. The combination therapy comprises a compound that increases BMPR2 signaling (BMPR2 activator) in combination with at least one other agent for the treatment of pulmonary hypertension. In certain aspects, the BMPR2 activator can be tacrolimus or a pharmaceutically acceptable solvate, salt, or prodrug thereof.
IPC 8 full level
A61P 9/12 (2006.01); A61K 31/4025 (2006.01); A61K 31/422 (2006.01); A61K 31/436 (2006.01); A61K 31/497 (2006.01); A61K 31/4985 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); A61K 31/5575 (2006.01); A61K 31/5585 (2006.01)
CPC (source: EP KR US)
A61K 31/4025 (2013.01 - EP KR US); A61K 31/422 (2013.01 - EP US); A61K 31/436 (2013.01 - EP KR US); A61K 31/497 (2013.01 - EP KR US); A61K 31/4985 (2013.01 - EP KR US); A61K 31/505 (2013.01 - EP KR US); A61K 31/506 (2013.01 - EP KR US); A61K 31/519 (2013.01 - EP KR US); A61K 31/53 (2013.01 - EP KR US); A61K 31/5575 (2013.01 - EP US); A61K 31/5585 (2013.01 - EP KR US); A61K 45/06 (2013.01 - EP KR US); A61P 11/00 (2018.01 - EP US); A61K 2300/00 (2013.01 - KR)
C-Set (source: EP US)
Citation (search report)
- [XP] EDDA SPIEKERKOETTER ET AL: "CORRESPONDENCE Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICIN, vol. 192, no. 2, 15 July 2015 (2015-07-15), pages 254 - 257, XP055494613
- [XY] EDDA SPIEKERKOETTER ET AL: "FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension", JOURNAL OF CLINICAL INVESTIGATION, vol. 123, no. 8, 15 July 2013 (2013-07-15), pages 3600 - 3613, XP055140950, ISSN: 0021-9738, DOI: 10.1172/JCI65592
- [Y] GREGORY P. STAR ET AL: "ALK2 and BMPR2 knockdown and endothelin-1 production by pulmonary microvascular endothelial cells", MICROVASCULAR RESEARCH., vol. 85, 1 January 2013 (2013-01-01), US, pages 46 - 53, XP055494614, ISSN: 0026-2862, DOI: 10.1016/j.mvr.2012.10.012
- See also references of WO 2016114993A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2016114993 A1 20160721; AU 2016207046 A1 20170727; AU 2016207046 B2 20210401; BR 112017014914 A2 20180313; BR 112017014914 B1 20231114; CA 2973114 A1 20160721; CA 2973114 C 20230404; CN 107427698 A 20171201; EP 3244968 A1 20171122; EP 3244968 A4 20180912; EP 3244968 B1 20230830; IL 253325 A0 20170928; JP 2018502126 A 20180125; JP 6890540 B2 20210618; KR 102569428 B1 20230821; KR 20170103918 A 20170913; MX 2017009110 A 20171109; NZ 733451 A 20230224; RU 2017128481 A 20190214; RU 2017128481 A3 20190625; US 2018325875 A1 20181115; US 2020069658 A1 20200305; US 2021267951 A1 20210902
DOCDB simple family (application)
US 2016012694 W 20160108; AU 2016207046 A 20160108; BR 112017014914 A 20160108; CA 2973114 A 20160108; CN 201680015289 A 20160108; EP 16737651 A 20160108; IL 25332517 A 20170705; JP 2017536934 A 20160108; KR 20177022273 A 20160108; MX 2017009110 A 20160108; NZ 73345116 A 20160108; RU 2017128481 A 20160108; US 201615543510 A 20160108; US 201916381128 A 20190411; US 202117317274 A 20210511