EP 3253890 A4 20180627 - TNFRSF-BINDING AGENTS AND USES THEREOF
Title (en)
TNFRSF-BINDING AGENTS AND USES THEREOF
Title (de)
TNFRSF-BINDENDE WIRKSTOFFE UND VERWENDUNGEN DAVON
Title (fr)
AGENTS DE LIAISON À LA TNFRSF ET LEURS UTILISATIONS
Publication
Application
Priority
- US 201562111404 P 20150203
- US 201562153272 P 20150427
- US 201562154008 P 20150428
- US 201562218956 P 20150915
- US 201562259129 P 20151124
- US 2016016306 W 20160203
Abstract (en)
[origin: WO2016126781A1] Polypeptides and agents that bind a TNF receptor superfamily protein are disclosed, particularly agents that specifically bind GITR, OX40, or CD40. The polypeptides or agents may include fusion polypeptides, particularly polypeptides comprising GITRL, OX40L, or CD40L and/or bispecific agents. Also disclosed are methods of using the polypeptides or agents for inducing and/or enhancing the immune response, as well as methods for the treatment of diseases such as cancer.
IPC 8 full level
C07H 21/04 (2006.01); C07K 14/00 (2006.01); C12N 15/00 (2006.01); C12N 15/19 (2006.01); C12N 15/62 (2006.01); C12Q 1/68 (2018.01)
CPC (source: CN EP KR US)
A61K 38/19 (2013.01 - EP KR US); A61K 39/39558 (2013.01 - KR US); A61K 45/06 (2013.01 - KR US); A61P 31/12 (2017.12 - CN EP); A61P 35/00 (2017.12 - CN EP); A61P 35/02 (2017.12 - CN EP); A61P 37/04 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/00 (2013.01 - US); C07K 14/52 (2013.01 - US); C07K 14/525 (2013.01 - EP KR US); C07K 14/70575 (2013.01 - CN); C07K 14/7151 (2013.01 - EP US); C07K 16/18 (2013.01 - US); C07K 16/2875 (2013.01 - KR); C12N 15/00 (2013.01 - US); C12N 15/62 (2013.01 - US); C12Q 1/68 (2013.01 - US); A61K 2039/505 (2013.01 - CN KR US); C07K 2317/31 (2013.01 - CN KR US); C07K 2317/55 (2013.01 - KR US); C07K 2317/622 (2013.01 - KR US); C07K 2317/73 (2013.01 - KR US); C07K 2319/30 (2013.01 - CN KR US)
Citation (search report)
- [X] WO 2010010051 A1 20100128 - APOGENIX GMBH [DE], et al
- [A] WO 2012130471 A1 20121004 - UNIV STUTTGART [DE], et al
- [A] WO 2014145355 A1 20140918 - STONE GEOFFREY W [US], et al
- [A] BERG D ET AL: "Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L", CELL DEATH AND DIFFERENTIATION, NATURE PUBLISHING GROUP, GB, vol. 14, no. 12, 1 December 2007 (2007-12-01), pages 2021 - 2034, XP002461745, ISSN: 1350-9047, DOI: 10.1038/SJ.CDD.4402213
- [A] A. WYZGOL ET AL: "Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand", THE JOURNAL OF IMMUNOLOGY, vol. 183, no. 3, 1 August 2009 (2009-08-01), pages 1851 - 1861, XP055015511, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0802597
- See references of WO 2016126781A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2016126781 A1 20160811; WO 2016126781 A4 20161013; AU 2016215394 A1 20170803; BR 112017016705 A2 20180410; CA 2975596 A1 20160811; CN 107406878 A 20171128; CN 109180804 A 20190111; CO 2017008047 A2 20180105; EA 201791313 A1 20180228; EP 3253890 A1 20171213; EP 3253890 A4 20180627; HK 1243741 A1 20180720; IL 253433 A0 20170928; JP 2018508233 A 20180329; KR 20170108073 A 20170926; MA 41460 A 20171212; MX 2017009793 A 20171027; PH 12017501372 A1 20171218; SG 11201706268X A 20170830; TW 201643184 A 20161216; US 10232017 B2 20190319; US 2016256527 A1 20160908; US 2018021407 A1 20180125; US 9724390 B2 20170808
DOCDB simple family (application)
US 2016016306 W 20160203; AU 2016215394 A 20160203; BR 112017016705 A 20160203; CA 2975596 A 20160203; CN 201680008684 A 20160203; CN 201810642593 A 20160203; CO 2017008047 A 20170809; EA 201791313 A 20160203; EP 16747162 A 20160203; HK 18103319 A 20180309; IL 25343317 A 20170712; JP 2017559287 A 20160203; KR 20177023582 A 20160203; MA 41460 A 20160202; MX 2017009793 A 20160203; PH 12017501372 A 20170731; SG 11201706268X A 20160203; TW 105103619 A 20160203; US 201615014134 A 20160203; US 201715636711 A 20170629