EP 3263095 A1 20180103 - A PHARMACEUTICAL FORMULATION OF OLAPARIB
Title (en)
A PHARMACEUTICAL FORMULATION OF OLAPARIB
Title (de)
PHARMAZEUTISCHE OLAPARIB-FORMULATION
Title (fr)
UNE FORMULATION PHARMACEUTIQUE DE L'OLAPARIBE
Publication
Application
Priority
CZ 2016391 A 20160629
Abstract (en)
The present invention relates to novel pharmaceutical preparations containing olaparib of formula I , systematically 4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fluorophenyl]methyl(2H)-phtalazin-1-one, with enhanced bioavailability, stability, or possibly reduced dosage of the active ingredient, a preparation method of these drug forms and their use for the treatment of cancer.
IPC 8 full level
A61K 9/14 (2006.01); A61K 31/502 (2006.01)
CPC (source: EP)
A61K 9/146 (2013.01); A61K 31/502 (2013.01)
Citation (applicant)
- WO 2004080976 A1 20040923 - KUDOS PHARM LTD [GB], et al
- WO 2008047082 A2 20080424 - KUDOS PHARM LTD [GB], et al
- WO 2009050469 A1 20090423 - KUDOS PHARM LTD [GB], et al
- WO 2010041051 A1 20100415 - ASTRAZENECA UK LTD [GB], et al
- EUROPEAN MEDICINES AGENCY, 23 October 2014 (2014-10-23)
Citation (search report)
- [XD] WO 2010041051 A1 20100415 - ASTRAZENECA UK LTD [GB], et al
- [A] YU L ED - KWON ICK CHAN ET AL: "AMORPHOUS PHARMACEUTICAL SOLIDS: PREPARATION, CHARACTERIZATION AND STABILIZATION", ADVANCED DRUG DELIVERY REV, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 1, 16 May 2001 (2001-05-16), pages 27 - 42, XP009065056, ISSN: 0169-409X, DOI: 10.1016/S0169-409X(01)00098-9
- [A] VASCONCELOS ET AL: "Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs", DRUG DISCOVERY TODAY, ELSEVIER, AMSTERDAM, NL, vol. 12, no. 23-24, 30 October 2007 (2007-10-30), pages 1068 - 1075, XP022370275, ISSN: 1359-6446
- [A] HANCOCK B C ET AL: "THE RELATIONSHIP BETWEEN THE GLASS TRANSITION TEMPERATURE AND THE WATER CONTENT OF AMORPHOUS PHARMACEUTICAL SOLIDS", PHARMACEUTICAL RESE, SPRINGER NEW YORK LLC, US, vol. 11, no. 4, 1 April 1994 (1994-04-01), pages 471 - 477, XP008031768, ISSN: 0724-8741, DOI: 10.1023/A:1018941810744
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
EP 17020256 A 20170619; CZ 2016391 A 20160629