Global Patent Index - EP 3263095 A1

EP 3263095 A1 20180103 - A PHARMACEUTICAL FORMULATION OF OLAPARIB

Title (en)

A PHARMACEUTICAL FORMULATION OF OLAPARIB

Title (de)

PHARMAZEUTISCHE OLAPARIB-FORMULATION

Title (fr)

UNE FORMULATION PHARMACEUTIQUE DE L'OLAPARIBE

Publication

EP 3263095 A1 20180103 (EN)

Application

EP 17020256 A 20170619

Priority

CZ 2016391 A 20160629

Abstract (en)

The present invention relates to novel pharmaceutical preparations containing olaparib of formula I , systematically 4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fluorophenyl]methyl(2H)-phtalazin-1-one, with enhanced bioavailability, stability, or possibly reduced dosage of the active ingredient, a preparation method of these drug forms and their use for the treatment of cancer.

IPC 8 full level

A61K 9/14 (2006.01); A61K 31/502 (2006.01)

CPC (source: EP)

A61K 9/146 (2013.01); A61K 31/502 (2013.01)

Citation (applicant)

Citation (search report)

  • [XD] WO 2010041051 A1 20100415 - ASTRAZENECA UK LTD [GB], et al
  • [A] YU L ED - KWON ICK CHAN ET AL: "AMORPHOUS PHARMACEUTICAL SOLIDS: PREPARATION, CHARACTERIZATION AND STABILIZATION", ADVANCED DRUG DELIVERY REV, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 1, 16 May 2001 (2001-05-16), pages 27 - 42, XP009065056, ISSN: 0169-409X, DOI: 10.1016/S0169-409X(01)00098-9
  • [A] VASCONCELOS ET AL: "Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs", DRUG DISCOVERY TODAY, ELSEVIER, AMSTERDAM, NL, vol. 12, no. 23-24, 30 October 2007 (2007-10-30), pages 1068 - 1075, XP022370275, ISSN: 1359-6446
  • [A] HANCOCK B C ET AL: "THE RELATIONSHIP BETWEEN THE GLASS TRANSITION TEMPERATURE AND THE WATER CONTENT OF AMORPHOUS PHARMACEUTICAL SOLIDS", PHARMACEUTICAL RESE, SPRINGER NEW YORK LLC, US, vol. 11, no. 4, 1 April 1994 (1994-04-01), pages 471 - 477, XP008031768, ISSN: 0724-8741, DOI: 10.1023/A:1018941810744

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3263095 A1 20180103; CZ 2016391 A3 20180110

DOCDB simple family (application)

EP 17020256 A 20170619; CZ 2016391 A 20160629