EP 3280402 B1 20240605 - TOLAN COMPOUNDS FOR PROMOTING WOUND HEALING
Title (en)
TOLAN COMPOUNDS FOR PROMOTING WOUND HEALING
Title (de)
TOLAN-VERBINDUNGEN ZUR FÖRDERUNG DER WUNDHEILUNG
Title (fr)
COMPOSÉS DE TOLANE POUR FAVORISER LA CICATRISATION DES PLAIES
Publication
Application
Priority
- US 201562144539 P 20150408
- US 2016026355 W 20160407
Abstract (en)
[origin: WO2016164531A2] Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I) wherein: L represents a linker selected from -C≡C-, (a tolan), -CH=CH- (a stilbene, preferably trans); or -CRa=CRb- a stilbene derivative; where Ra and Rb are independently H or phenyl optionally substituted with -(R3)p or -(R4)q; R1 to R4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3', 4, 4', and/or 5, 5'; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R1 to R2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.
IPC 8 full level
A61K 31/047 (2006.01); A61K 9/00 (2006.01); A61K 31/01 (2006.01); A61K 31/03 (2006.01); A61K 31/05 (2006.01); A61K 31/085 (2006.01); A61K 31/09 (2006.01); A61K 31/122 (2006.01); A61K 31/136 (2006.01); A61K 31/167 (2006.01); A61K 31/655 (2006.01); A61K 31/7034 (2006.01); A61P 17/00 (2006.01); A61P 29/00 (2006.01)
CPC (source: EP IL KR US)
A61K 8/33 (2013.01 - EP IL US); A61K 8/347 (2013.01 - EP IL KR US); A61K 8/602 (2013.01 - EP IL US); A61K 8/676 (2013.01 - EP IL US); A61K 8/70 (2013.01 - EP IL US); A61K 8/733 (2013.01 - EP IL US); A61K 8/738 (2013.01 - EP IL US); A61K 9/0019 (2013.01 - EP IL US); A61K 9/06 (2013.01 - EP IL KR US); A61K 9/08 (2013.01 - EP IL US); A61K 9/19 (2013.01 - EP IL US); A61K 31/03 (2013.01 - EP IL US); A61K 31/047 (2013.01 - IL KR); A61K 31/05 (2013.01 - EP IL KR US); A61K 31/085 (2013.01 - EP IL KR US); A61K 31/09 (2013.01 - EP IL KR US); A61K 31/167 (2013.01 - EP IL KR US); A61K 31/375 (2013.01 - EP IL KR US); A61K 31/655 (2013.01 - EP IL US); A61K 31/7034 (2013.01 - EP IL KR US); A61K 45/06 (2013.01 - EP IL US); A61K 47/36 (2013.01 - IL US); A61K 47/40 (2013.01 - EP IL US); A61P 1/04 (2018.01 - EP IL); A61P 1/16 (2018.01 - EP IL); A61P 3/02 (2018.01 - EP IL); A61P 3/10 (2018.01 - EP IL); A61P 7/06 (2018.01 - EP IL); A61P 9/10 (2018.01 - EP IL); A61P 11/06 (2018.01 - EP IL); A61P 13/12 (2018.01 - EP IL); A61P 15/00 (2018.01 - EP IL); A61P 17/00 (2018.01 - EP IL); A61P 17/02 (2018.01 - EP IL KR); A61P 17/06 (2018.01 - EP IL); A61P 17/14 (2018.01 - EP IL); A61P 19/02 (2018.01 - EP IL); A61P 19/06 (2018.01 - EP IL); A61P 19/10 (2018.01 - EP IL); A61P 25/00 (2018.01 - EP IL); A61P 25/16 (2018.01 - EP IL); A61P 25/28 (2018.01 - EP IL); A61P 27/02 (2018.01 - EP IL); A61P 29/00 (2018.01 - EP IL); A61P 31/04 (2018.01 - EP IL); A61P 31/12 (2018.01 - EP IL); A61P 33/00 (2018.01 - EP IL); A61P 35/00 (2018.01 - EP IL); A61P 37/06 (2018.01 - EP IL); A61P 43/00 (2018.01 - EP IL); A61Q 7/00 (2013.01 - EP IL US); A61Q 19/08 (2013.01 - EP IL KR US); A61K 2300/00 (2013.01 - IL KR); Y02A 50/30 (2018.01 - EP US)
C-Set (source: EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2016164531 A2 20161013; WO 2016164531 A3 20161117; AU 2016246616 A1 20171019; AU 2016246616 B2 20210401; BR 112017021271 A2 20180626; CA 2982161 A1 20161013; CA 2982161 C 20230718; CN 107847466 A 20180327; CN 107847466 B 20240206; EP 3280402 A2 20180214; EP 3280402 A4 20190403; EP 3280402 B1 20240605; HK 1251836 A1 20190412; IL 254863 A0 20171231; IL 254863 B 20210630; JP 2018510902 A 20180419; JP 2021073273 A 20210513; JP 6927884 B2 20210901; KR 20170141705 A 20171226; MX 2017012727 A 20180528; MY 191791 A 20220715; SG 11201707919Q A 20171030; US 10045950 B2 20180814; US 10426742 B2 20191001; US 11786481 B2 20231017; US 2016296477 A1 20161013; US 2019022029 A1 20190124; US 2020016096 A1 20200116; US 2021228501 A1 20210729
DOCDB simple family (application)
US 2016026355 W 20160407; AU 2016246616 A 20160407; BR 112017021271 A 20160407; CA 2982161 A 20160407; CN 201680023068 A 20160407; EP 16777246 A 20160407; HK 18111272 A 20180903; IL 25486317 A 20171003; JP 2017553168 A 20160407; JP 2021014601 A 20210201; KR 20177032280 A 20160407; MX 2017012727 A 20160407; MY PI2017703652 A 20160407; SG 11201707919Q A 20160407; US 201615093146 A 20160407; US 201816058437 A 20180808; US 201916584195 A 20190926; US 202117221181 A 20210402