EP 3288593 A1 20180307 - CONJUGATE OF MONOMETHYL AURISTATIN F AND TRASTUZUMAB AND ITS USE FOR THE TREATMENT OF CANCER
Title (en)
CONJUGATE OF MONOMETHYL AURISTATIN F AND TRASTUZUMAB AND ITS USE FOR THE TREATMENT OF CANCER
Title (de)
KONJUGAT VON MONOMETHYL AURISTATIN F UND TRASTUZUMAB UND DESSEN VERWENDUNG ZUR BEHANDLUNG VON KREBS
Title (fr)
CONJUGUÉ DE MONOMÉTHYLE AURISTATINE F ET DE TRASTUZUMAB ET SON UTILISATION POUR LE TRAITEMENT DU CANCER
Publication
Application
Priority
- EP 2015059052 W 20150427
- EP 2015074766 W 20151026
Abstract (en)
[origin: WO2016173682A1] The present invention relates to an antibody-drug-conjugate. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody consisting of the Trastuzumab, said antibody being conjugated to at least one drug consisting of a monomethyl auristatin F derivative. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.
IPC 8 full level
A61P 35/00 (2006.01)
CPC (source: EP)
A61K 47/68031 (2023.08); A61K 47/6855 (2017.08); A61P 35/00 (2018.01)
Citation (examination)
- ELSA WAGNER-ROUSSET ET AL: "Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion", MABS, vol. 6, no. 1, 17 October 2013 (2013-10-17), pages 173 - 184, XP055214670, ISSN: 1942-0870, DOI: 10.4161/mabs.26773
- ELSA WAGNER-ROUSSET ET AL: "Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion", MABS, vol. 6, no. 1, 17 October 2013 (2013-10-17), pages 173 - 184, XP055214670, ISSN: 1942-0870, DOI: 10.4161/mabs.26773
- DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; April 2007 (2007-04-01), LEIPOLD DOUGLAS D ET AL: "Trastuzumab-MC-vc-PAB-MMAF: The effects of the Drug: Antibody Ratio (DAR) on efficacy, toxicity and pharmacokinetics.", XP002798872, Database accession no. PREV200700304302 & PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 48, April 2007 (2007-04-01), 98TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-CANCER-RESEARCH; LOS ANGELES, CA, USA; APRIL 14 -18, 2007, pages 368 - 369, ISSN: 0197-016X
- See also references of WO 2016173682A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
EP 2015074766 W 20151026; EP 15785105 A 20151026