EP 3292213 A1 20180314 - BIOMARKERS FOR THE DETECTION OF ASPIRIN INSENSITIVITY
Title (en)
BIOMARKERS FOR THE DETECTION OF ASPIRIN INSENSITIVITY
Title (de)
BIOMARKER FÜR DEN NACHWEIS VON ASPIRINUNEMPFINDLICHKEIT
Title (fr)
BIOMARQUEURS POUR LA DÉTECTION DE L'INSENSIBILITÉ À L'ASPIRINE
Publication
Application
Priority
- EP 15166277 A 20150504
- EP 2016059991 W 20160504
Abstract (en)
[origin: WO2016177776A1] The invention provides a method for determining whether a patient is sensitive or insensitive to a treatment with a thromboxane A2 inhibitor or a selective COX-1 inhibitor for use in a platelet inhibition treatment comprising the steps of: a. determining the expression level of one or more mi RNA(s) selected from the group consisting of miR-19b-1-5p, miR-1271, and miR-1537-5p, in a sample comprising platelet derived nucleic acids, b. comparing said expression level with a reference level, and c. determining the sensitivity or insensitivity of said subject for a treatment with said thromboxane A2 inhibitor or said selective COX-1 inhibitor based on the information obtained in step b.
IPC 8 full level
C12Q 1/68 (2018.01); C12N 15/113 (2010.01)
CPC (source: EP)
C12N 15/111 (2013.01); C12Q 1/6883 (2013.01); C12N 2310/141 (2013.01); C12N 2320/10 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01)
Citation (search report)
See references of WO 2016177776A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
EP 2016059991 W 20160504; EP 16720828 A 20160504