EP 3298167 A4 20190116 - GENE EXPRESSION PROFILES AND USES THEREOF IN BREAST CANCER

Title (en)

GENE EXPRESSION PROFILES AND USES THEREOF IN BREAST CANCER

Title (de)

GENEXPRESSIONSPROFILE UND VERWENDUNGEN DAVON BEI BRUSTKREBS

Title (fr)

PROFILS D'EXPRESSION GÉNIQUE ET UTILISATIONS DE CEUX-CI DANS LE CANCER DU SEIN

Publication

EP 3298167 A4 20190116 (EN)

Application

EP 16796852 A 20160519

Priority

TW 104115832 A 20150519
SG 2016050238 W 20160519

Abstract (en)

[origin: WO2016186582A2] A method for predicting the likelihood of locoregional recurrence (LRR) and/or distant metastasis in a subject with breast cancer following mastectomy and/or breast conserving surgery, comprising: measuring the expression level of at least one gene in a sample isolated from the subject; and deriving a score based on the measured expression level of the at least one gene, wherein the at least one gene is selected from a group consisting of TRPV6, DDX39, BUB1B, CCR1, STIL, BLM, C16ORF7, TPX2, PTI1, TCF3, CCNB1, DTX2, PIM1, ENSA, RCHY1, NFATC2IP, OBSL1, and MMP15, and wherein the derived score provides an indication of the likelihood of LRR and/or the likelihood of distant metastasis in the subject.

IPC 8 full level

C12Q 1/68 (2018.01); G16B 40/20 (2019.01)

CPC (source: EP KR US)

C12Q 1/6886 (2013.01 - EP KR US); G16B 40/00 (2019.01 - EP US); G16B 40/20 (2019.01 - EP US); C12Q 2600/118 (2013.01 - EP KR US); C12Q 2600/158 (2013.01 - EP KR US)

Citation (search report)

[X] WO 2008094678 A2 20080807 - APPLERA CORP [US], et al
[X] WO 2006110264 A2 20061019 - SIDNEY KIMMEL CANCER CT [US], et al
[A] WO 2013132354 A2 20130912 - UNIV OSLO HF [NO], et al
See references of WO 2016186582A2

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2016186582 A2 20161124; WO 2016186582 A3 20170330; CN 107614696 A 20180119; EP 3298167 A2 20180328; EP 3298167 A4 20190116; EP 3298167 B1 20210120; HK 1252038 A1 20190510; JP 2018515124 A 20180614; JP 6931926 B2 20210908; KR 20180002882 A 20180108; TW 201641693 A 20161201; TW 201741915 A 20171201; TW I582240 B 20170511; TW I622892 B 20180501; US 2018298449 A1 20181018

DOCDB simple family (application)

SG 2016050238 W 20160519; CN 201680003592 A 20160519; EP 16796852 A 20160519; HK 18111370 A 20180905; JP 2017560653 A 20160519; KR 20177036467 A 20160519; TW 104115832 A 20150519; TW 106115393 A 20170510; US 201615575139 A 20160519