Global Patent Index - EP 3307785 A4

EP 3307785 A4 20181205 - METHOD FOR THE IN SITU FORMATION OF BIFUNCTIONAL IMMUNOLOGICAL COMPLEXES

Title (en)

METHOD FOR THE IN SITU FORMATION OF BIFUNCTIONAL IMMUNOLOGICAL COMPLEXES

Title (de)

VERFAHREN ZUR IN SITU-HERSTELLUNG VON BIFUNKTIONELLEN IMMUNOLOGISCHEN KOMPLEXEN

Title (fr)

PROCÉDÉ DE FORMATION IN SITU DE COMPLEXES IMMUNOLOGIQUES BIFONCTIONNELS

Publication

EP 3307785 A4 20181205 (EN)

Application

EP 16806469 A 20160603

Priority

  • US 201562173600 P 20150610
  • CA 2016050631 W 20160603

Abstract (en)

[origin: WO2016197238A1] An improved method for the preparation of tetrameric antibody complexes directly on the surface of target entities in a sample is described. In particular, this method involves linking, in the sample, a first target entity with a second target entity in a sample using antibodies with specificity for the first and second target entities.

IPC 8 full level

C07K 16/46 (2006.01); C07K 1/22 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/42 (2006.01); C12N 1/02 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/566 (2006.01)

CPC (source: EP US)

C07K 1/22 (2013.01 - US); C07K 16/00 (2013.01 - EP US); C07K 16/283 (2013.01 - EP US); C07K 16/2866 (2013.01 - EP US); C07K 16/4283 (2013.01 - EP US); C07K 16/44 (2013.01 - EP US); G01N 33/54313 (2013.01 - EP US); G01N 33/54326 (2013.01 - EP US); G01N 33/56977 (2013.01 - EP US); G01N 33/80 (2013.01 - EP US); C07K 2317/31 (2013.01 - EP US); C07K 2317/32 (2013.01 - US); C07K 2317/35 (2013.01 - EP US)

Citation (search report)

  • [X] US 4868109 A 19890919 - LANSDORP PETER M [CA]
  • [X] GORDON R ET AL: "A simple magnetic separation method for high-yield isolation of pure primary microglia", JOURNAL OF NEUROSCIENCE METHODS, ELSEVIER SCIENCE PUBLISHER B.V., AMSTERDAM, NL, vol. 194, no. 2, 15 January 2011 (2011-01-15), pages 287 - 296, XP027574484, ISSN: 0165-0270, [retrieved on 20101224]
  • [I] KUHARA M ET AL: "MAGNETIC CELL SEPARATION USING ANTIBODY BINDING WITH PROTEIN A EXPRESSED ON BACTERIAL MAGNETIC PARTICLES", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 76, no. 21, 1 November 2004 (2004-11-01), pages 6207 - 6213, XP001226098, ISSN: 0003-2700, DOI: 10.1021/AC0493727

Citation (examination)

  • LANSDORP P M ET AL: "CYCLIC TETRAMOLECULAR COMPLEXES OF MONOCLONAL ANTIBODIES: A NEW TYPE OF CROSS-LINKING REAGENT", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY VCH, WEINHEIM, vol. 16, no. 6, 1 January 1986 (1986-01-01), pages 679 - 683, XP009077557, ISSN: 0014-2980, DOI: 10.1002/EJI.1830160615
  • LANSDORP P M ET AL: "Purification and analysis of bispecific tetrameric antibody complexes", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 27, no. 7, 1 July 1990 (1990-07-01), pages 659 - 666, XP023681432, ISSN: 0161-5890, [retrieved on 19900701], DOI: 10.1016/0161-5890(90)90009-O
  • VAN DER KANT ROB ET AL: "Prediction and Reduction of the Aggregation of Monoclonal Antibodies", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, 18 March 2017 (2017-03-18), XP085100467, ISSN: 0022-2836, DOI: 10.1016/J.JMB.2017.03.014
  • JONES D S ET AL: "Developing therapeutic proteins by engineering ligand-receptor interactions", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 26, no. 9, 1 September 2008 (2008-09-01), pages 498 - 505, XP023783699, ISSN: 0167-7799, [retrieved on 20080731], DOI: 10.1016/J.TIBTECH.2008.05.009
  • C ADAMS ET AL: "Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5", CELL DEATH AND DIFFERENTIATION, vol. 15, no. 4, 1 April 2008 (2008-04-01), pages 751 - 761, XP055027452, ISSN: 1350-9047, DOI: 10.1038/sj.cdd.4402306
  • S. PASTOR ET AL: "Analyses of TCR clustering at the T cell-antigen-presenting cell interface and its impact on the activation of naive CD4+ T cells", INTERNATIONAL IMMUNOLOGY, vol. 18, no. 11, 5 September 2006 (2006-09-05), pages 1615 - 1625, XP055677207, ISSN: 0953-8178, DOI: 10.1093/intimm/dxl095
  • See also references of WO 2016197238A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2016197238 A1 20161215; CN 107709366 A 20180216; CN 107709366 B 20211026; EP 3307785 A1 20180418; EP 3307785 A4 20181205; US 10983114 B2 20210420; US 2018188245 A1 20180705

DOCDB simple family (application)

CA 2016050631 W 20160603; CN 201680036299 A 20160603; EP 16806469 A 20160603; US 201615580708 A 20160603