EP 3308153 A4 20190220 - GRAPHENE FET DEVICES, SYSTEMS, AND METHODS OF USING THE SAME FOR SEQUENCING NUCLEIC ACIDS
Title (en)
GRAPHENE FET DEVICES, SYSTEMS, AND METHODS OF USING THE SAME FOR SEQUENCING NUCLEIC ACIDS
Title (de)
GRAPHEN-FET-VORRICHTUNGEN, SYSTEME UND VERFAHREN ZUR VERWENDUNG DAVON ZUR SEQUENZIERUNG VON NUKLEINSÄUREN
Title (fr)
DISPOSITIFS À FET AU GRAPHÈNE, SYSTÈMES ET LEURS MÉTHODES D'UTILISATION POUR LE SÉQUENÇAGE D'ACIDES NUCLÉIQUES
Publication
Application
Priority
- US 201562175384 P 20150614
- US 201562175351 P 20150614
- US 201562175649 P 20150615
- US 2016037448 W 20160614
Abstract (en)
[origin: WO2016205253A1] Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes, including DNA hybridization and/or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor.
IPC 8 full level
G01N 27/414 (2006.01); H01L 21/4763 (2006.01); H01L 21/768 (2006.01); H01L 29/16 (2006.01)
CPC (source: EP)
G01N 27/414 (2013.01); H01L 21/8258 (2013.01); H01L 27/0688 (2013.01); H01L 29/1606 (2013.01); H01L 29/41733 (2013.01); H01L 29/45 (2013.01); H01L 29/66742 (2013.01); H01L 29/78681 (2013.01); H01L 29/78684 (2013.01); B82Y 10/00 (2013.01); B82Y 30/00 (2013.01); H01L 27/092 (2013.01)
Citation (search report)
- [Y] WO 2014024598 A1 20140213 - HITACHI HIGH TECH CORP [JP] & US 2015308977 A1 20151029 - SAITO TOSHIRO [JP], et al
- [A] US 2010176463 A1 20100715 - KOIZUMI KOSHIRO [JP], et al
- [Y] BARAKET MIRA ET AL: "Aminated graphene for DNA attachment produced via plasma functionalization", APPLIED PHYSICS LETTERS, A I P PUBLISHING LLC, US, vol. 100, no. 23, 4 June 2012 (2012-06-04), pages 233123 - 233123, XP012156487, ISSN: 0003-6951, [retrieved on 20120608], DOI: 10.1063/1.4711771
- See references of WO 2016205253A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2016205253 A1 20161222; EP 3308153 A1 20180418; EP 3308153 A4 20190220
DOCDB simple family (application)
US 2016037448 W 20160614; EP 16812262 A 20160614