Global Patent Index - EP 3317246 A4

EP 3317246 A4 20190227 - SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE

Title (en)

SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE

Title (de)

SPEZIFISCHE KONJUGATION EINES ZELLBINDENDEN MOLEKÜLS

Title (fr)

CONJUGAISON SPÉCIFIQUE D'UNE MOLÉCULE DE LIAISON CELLULAIRE

Publication

EP 3317246 A4 20190227 (EN)

Application

EP 15772625 A 20150704

Priority

IB 2015055051 W 20150704

Abstract (en)

[origin: WO2015151080A2] Cell binding agent-drug conjugates comprising bridge linkers, and methods of using such linkers and conjugates are provided.

IPC 8 full level

A61K 47/68 (2017.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C07C 59/76 (2006.01); C07C 237/52 (2006.01); C07D 207/46 (2006.01); C07D 417/14 (2006.01); C07K 16/28 (2006.01)

CPC (source: EP US)

A61K 47/6803 (2017.08 - EP US); A61K 47/68031 (2023.08 - EP US); A61K 47/68033 (2023.08 - EP US); A61K 47/6855 (2017.08 - EP); A61K 47/6869 (2017.08 - EP); A61K 47/6889 (2017.08 - EP); A61P 31/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07C 59/76 (2013.01 - EP); C07C 233/20 (2013.01 - EP US); C07D 207/46 (2013.01 - EP); C07D 417/14 (2013.01 - EP)

Citation (search report)

  • [X] CN 101723961 A 20100609 - CHAOMEI LIU
  • [X] DIRK HEYL ET AL: "Facile Direct Synthesis of Acetylenedicarboxamides", SYNTHESIS, vol. 46, no. 11, 17 March 2014 (2014-03-17), STUTTGART, DE., pages 1463 - 1468, XP055450898, ISSN: 0039-7881, DOI: 10.1055/s-0033-1341101
  • [X] JOHN A. MIKROYANNIDIS ET AL: "Synthesis, photophysics, structure-tunable photoluminescence, and electrochemical properties of soluble poly(p-phenylenevinylene)-based polymers with adjacent 1,3,4-oxadiazoles in the backbone", JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, vol. 43, no. 14, 1 January 2005 (2005-01-01), US, pages 3079 - 3090, XP055450904, ISSN: 0887-624X, DOI: 10.1002/pola.20771
  • [X] A. S. HASHMI: "Photochemical Synthesis of Prochiral Dialkyl 3,3-Dialkylcyclopropene-1,2- dicarboxylates with Facial Shielding Substituents and Related Substrates", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 26 November 2001 (2001-11-26), GB, pages 4705 - 4732, XP055450906, ISBN: 978-0-08-097742-3
  • [X] GRETE VAN WUYTSWINKEL ET AL: "A convergent synthesis of heterocyclic dendrimers using the 1,3-dipolar cycloaddition reaction of organic azides and acetylenedicarboxylate esters", ROYAL CHEMICAL SOCIETY. JOURNAL. PERKIN TRANSACTIONS 1, vol. 1, no. 9, 1 January 2000 (2000-01-01), GB, pages 1337 - 1340, XP055450907, ISSN: 1470-4358, DOI: 10.1039/b000025f
  • [X] J. L. CHARLTON: "'Synthesis of chiral Esters of Acetylenedicarboxylic Acid'", TETRAHEDRON LETTERS, vol. 35, no. 34, 22 August 1994 (1994-08-22), pages 6243 - 6246, XP055450908
  • [Y] JOÃO P. M. NUNES ET AL: "Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)", CHEMICAL COMMUNICATIONS, vol. 51, no. 53, 1 January 2015 (2015-01-01), pages 10624 - 10627, XP055539726, ISSN: 1359-7345, DOI: 10.1039/C5CC03557K
  • [Y] RAVI V. J. CHARI ET AL: "Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, no. 15, 7 April 2014 (2014-04-07), pages 3796 - 3827, XP055167825, ISSN: 1433-7851, DOI: 10.1002/anie.201307628
  • [A] LOURDES CASTAÑEDA ET AL: "Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation", CHEMICAL COMMUNICATIONS, vol. 49, no. 74, 1 January 2013 (2013-01-01), pages 8187 - 8189, XP055539224, ISSN: 1359-7345, DOI: 10.1039/c3cc45220d

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2015151080 A2 20151008; WO 2015151080 A3 20160602; CA 2991384 A1 20151008; CA 2991384 C 20221108; CN 108811499 A 20181113; CN 108811499 B 20210924; CN 113698335 A 20211126; EP 3317246 A2 20180509; EP 3317246 A4 20190227; JP 2018523639 A 20180823; JP 6700321 B2 20200527

DOCDB simple family (application)

IB 2015055051 W 20150704; CA 2991384 A 20150704; CN 201580082141 A 20150704; CN 202110978276 A 20150704; EP 15772625 A 20150704; JP 2017568455 A 20150704