EP 3317402 B1 20240214 - A VIABLE CELL POPULATION, METHOD FOR PRODUCTION AND USES THEREOF
Title (en)
A VIABLE CELL POPULATION, METHOD FOR PRODUCTION AND USES THEREOF
Title (de)
LEBENSFÄHIGE ZELLPOPULATION, VERFAHREN ZUR HERSTELLUNG UND VERWENDUNGEN DAVON
Title (fr)
POPULATION DE CELLULES VIABLES, PROCÉDÉ DE PRODUCTION ET UTILISATIONS DE CELLE-CI
Publication
Application
Priority
- PT 10862115 A 20150630
- IB 2016053901 W 20160629
Abstract (en)
[origin: WO2017002045A1] The present disclosure relates to a viable cell population, a method for production and uses thereof. The viable cell population of the present disclosure can be used in medicine, in particular in a method for the treatment of cancer, immune diseases, or viral or bacterial infections. This disclosure may also be suitable for cellular vaccine development. The viable cell population now disclosed has low sialic acid content, is loaded with specific antigens, shows higher antigen presentation, high maturation and co-stimulatory properties, and less tolerogenic properties. The present disclosure relates to a population of viable cells, wherein said population is obtainable by the maturation of the dendritic cells or T2 cells treated with sialidase during 45 min – overnight at 37 °C and, wherein the sialidase concentration vary between 0.002 U/mL - 0.005 U/mL per 1x106 of dendritic cells or T2 cells.
IPC 8 full level
C12N 5/0784 (2010.01); A61K 35/15 (2015.01)
CPC (source: EP US)
A61K 35/15 (2013.01 - EP); A61K 39/0011 (2013.01 - US); A61K 39/00115 (2018.08 - US); A61K 39/001157 (2018.08 - US); A61K 39/001164 (2018.08 - US); A61K 39/00117 (2018.08 - US); A61K 39/001182 (2018.08 - US); A61K 39/001184 (2018.08 - US); A61K 39/001189 (2018.08 - US); A61K 39/00119 (2018.08 - US); A61K 39/001191 (2018.08 - US); A61K 39/001192 (2018.08 - US); A61K 39/001195 (2018.08 - US); A61K 39/4615 (2023.05 - EP); A61K 39/4622 (2023.05 - EP); A61K 39/46449 (2023.05 - EP); A61K 39/464492 (2023.05 - EP); A61K 39/464499 (2023.05 - EP); C12N 5/0639 (2013.01 - EP); C12N 5/064 (2013.01 - EP); A61K 2039/572 (2013.01 - EP); C12N 2501/73 (2013.01 - EP)
Citation (examination)
- HÉLIO J. CRESPO ET AL: "Effect of sialic acid loss on dendritic cell maturation", IMMUNOLOGY, vol. 128, no. 1pt2, 1 September 2009 (2009-09-01), GB, pages e621 - e631, XP055300892, ISSN: 0019-2805, DOI: 10.1111/j.1365-2567.2009.03047.x
- DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; December 2010 (2010-12-01), STAMATOS NICHOLAS M ET AL: "LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity.", XP002761584, Database accession no. NLM20826611 & STAMATOS NICHOLAS M ET AL: "LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity", JOURNAL OF LEUKOCYTE BIOLOGY, JOHN WILEY & SONS LTD, GB, vol. 88, no. 6, 1 December 2010 (2010-12-01), pages 1227 - 1239, XP009191589, ISSN: 0741-5400
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017002045 A1 20170105; BR 112018000027 A2 20220906; EP 3317402 A1 20180509; EP 3317402 B1 20240214; EP 3317402 C0 20240214
DOCDB simple family (application)
IB 2016053901 W 20160629; BR 112018000027 A 20160629; EP 16741685 A 20160629