Global Patent Index - EP 3328372 A4

EP 3328372 A4 20190320 - COMPOSITIONS AND METHODS OF TREATING CANCER

Title (en)

COMPOSITIONS AND METHODS OF TREATING CANCER

Title (de)

ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON KREBS

Title (fr)

COMPOSITIONS ET MÉTHODES DE TRAITEMENT DU CANCER

Publication

EP 3328372 A4 20190320 (EN)

Application

EP 16831224 A 20160726

Priority

  • US 201562198001 P 20150728
  • US 201562241379 P 20151014
  • US 2016043993 W 20160726

Abstract (en)

[origin: WO2017019664A1] The invention provides compositions and methods to treat a hyperproliferative disorder with phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof and an anti-cancer composition.

IPC 8 full level

A61K 31/19 (2006.01); A61K 31/192 (2006.01); A61K 31/437 (2006.01); A61K 31/4706 (2006.01); A61K 31/66 (2006.01); A61K 31/662 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP US)

A61K 31/192 (2013.01 - EP US); A61K 31/437 (2013.01 - EP US); A61K 31/4706 (2013.01 - EP US); A61K 31/66 (2013.01 - EP US); A61K 31/662 (2013.01 - EP US); A61K 39/3955 (2013.01 - US); A61P 35/00 (2017.12 - EP US); C07K 16/2818 (2013.01 - US); C07K 2317/21 (2013.01 - US)

Citation (search report)

  • [I] BURKITT KYUNGHEE ET AL: "Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB, vol. 7, no. 1, 6 March 2008 (2008-03-06), pages 24, XP021036944, ISSN: 1476-4598
  • [XI] PHILLIPS J A ET AL: "Pilot study of sodium phenylbutyrate as adjuvant in cyclophosphamide-resistant endemic Burkitt's lymphoma", TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, ELSEVIER, GB, vol. 101, no. 12, 1 December 2007 (2007-12-01), pages 1265 - 1269, XP026864783, ISSN: 0035-9203, [retrieved on 20071029]
  • [I] GORE ET AL: "In vitro basis for treatment with hypomethylating agents and histone deacetylase inhibitors: can epigenetic changes be used to monitor treatment?", LEUKEMIA RESEARCH, NEW YORK,NY, US, vol. 33, 1 December 2009 (2009-12-01), pages S2 - S6, XP026796334, ISSN: 0145-2126, [retrieved on 20091201]
  • [I] SCHNIEWIND BODO ET AL: "Combination phenylbutyrate/gemcitabine therapy effectively inhibits in vitro and in vivo growth of NSCLC by intrinsic apoptotic pathways", JOURNAL OF CARCINOGENESIS, BIOMED CENTRAL, LONDON, GB, vol. 5, no. 1, 23 November 2006 (2006-11-23), pages 25, XP021024535, ISSN: 1477-3163, DOI: 10.1186/1477-3163-5-25
  • [I] FIGG WILLIAM D ET AL: "In vitro antitumor effect of hydroxyurea on hormone-refractory prostate cancer cells and its potentiation by phenylbutyrate", ANTI-CANCER DRUGS, vol. 5, no. 3, 1994, pages 336 - 342, XP009511041, ISSN: 0959-4973
  • See references of WO 2017019664A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2017019664 A1 20170202; AU 2016298175 A1 20180315; AU 2016298175 B2 20220106; EP 3328372 A1 20180606; EP 3328372 A4 20190320; US 10729669 B2 20200804; US 11596613 B2 20230307; US 2018214402 A1 20180802; US 2021113503 A1 20210422

DOCDB simple family (application)

US 2016043993 W 20160726; AU 2016298175 A 20160726; EP 16831224 A 20160726; US 201615748506 A 20160726; US 202016945327 A 20200731