EP 3331530 A4 20181219 - MTHFD2 INHIBITORS AND USES THEREOF
Title (en)
MTHFD2 INHIBITORS AND USES THEREOF
Title (de)
MTHFD2-INHIBITOREN UND VERWENDUNGEN DAVON
Title (fr)
INHIBITEURS DE MTHFD2 ET UTILISATION DESDITS INHIBITEURS
Publication
Application
Priority
- US 201562200243 P 20150803
- US 2016045086 W 20160802
Abstract (en)
[origin: WO2017023894A1] The present invention provides compounds, compositions thereof, and methods of using the same.
IPC 8 full level
C07D 403/12 (2006.01); A61K 31/497 (2006.01); A61P 35/00 (2006.01); C07D 209/14 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07D 209/14 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01)
Citation (search report)
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- [X] WO 2014137728 A1 20140912 - MERCK SHARP & DOHME [US], et al
- [X] US 5834493 A 19981110 - GIL QUINTERO MYRNA [IT], et al & DATABASE REAXYS [online] Elsevier Life Sciences IP Limited; 10 November 1998 (1998-11-10), QUINTER ET AL.: "Indole derivtives as 5-HT1A and/or 5-HT2 ligands", XP002786181, Database accession no. 13589235 (XRN)
- [X] WO 2012133509 A1 20121004 - DAINIPPON SUMITOMO PHARMA CO [JP], et al
- [X] CHO ET AL.: "Conformational Refinement of Hydroxamate-Based Histone Deacetylase Inhibitors and Exploration of 3-Piperidin-3-ylindole Analogues of Dacinostat (LAQ824)", J. MED. CHEM., vol. 53, no. 7, 1 January 2010 (2010-01-01), pages 2952 - 2963, XP002624311, ISSN: 0022-2623, [retrieved on 20100305], DOI: 10.1021/JM100007M
- [X] YANG ET AL.: "Highly Enantioselective Ring-Opening Reactions of Aziridines with Indole and Its Application in the Building of C 3 -Halogenated Pyrroloindolines", CHEMISTRY - A EUROPEAN JOURNAL, vol. 20, no. 50, 8 December 2014 (2014-12-08), DE, pages 16478 - 16483, XP055520223, ISSN: 0947-6539, DOI: 10.1002/chem.201404354
- [X] PRATT; BOTIMER: "Disproportionative Condensations. IV. The 3-Alkylation of Indoles by Primary and Secondary Alcohols 1", J. AM. CHEM. SOC., vol. 79, no. 19, 1 October 1957 (1957-10-01), pages 5248 - 5250, XP055520239, ISSN: 0002-7863, DOI: 10.1021/ja01576a049
- [X] GRAY: "Reductive Alkylation of Indole with Pyridinecarboxaldehydes", J. ORG. CHEM., vol. 23, no. 10, 1 October 1958 (1958-10-01), pages 1453 - 1454, XP055520241, ISSN: 0022-3263, DOI: 10.1021/jo01104a012
- [XI] ZAYTSEV ET AL.: "Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach", CHEM. BIOL. DRUG DES., vol. 86, no. 2, 11 November 2014 (2014-11-11), GB, pages 180 - 189, XP055520311, ISSN: 1747-0277, DOI: 10.1111/cbdd.12474
- [X] MLADENOVA ET AL.: "First-in-Class, Dual-Action, 3,5-Disubstituted Indole Derivatives Having Human Nitric Oxide Synthase (nNOS) and Norepinephrine Reuptake Inhibitory (NERI) Activity for the Treatment of Neuropathic Pain", J. MED. CHEM., vol. 55, no. 7, 4 April 2012 (2012-04-04), pages 3488 - 3501, XP055520349, ISSN: 0022-2623, DOI: 10.1021/jm300138g
- [A] TEDESCHI ET AL.: "Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development", MOL. CANCER RES., vol. 13, no. 10, 22 June 2015 (2015-06-22), US, pages 1361 - 1366, XP055520438, ISSN: 1541-7786, DOI: 10.1158/1541-7786.MCR-15-0117
- See references of WO 2017023894A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017023894 A1 20170209; EP 3331530 A1 20180613; EP 3331530 A4 20181219
DOCDB simple family (application)
US 2016045086 W 20160802; EP 16833713 A 20160802