EP 3331862 A1 20180613 - A PROCESS FOR PREPARATION OF SOLID IVABRADINE HYDROCHLORIDE
Title (en)
A PROCESS FOR PREPARATION OF SOLID IVABRADINE HYDROCHLORIDE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON FESTEM IVABRADINHYDROCHLORID
Title (fr)
PROCÉDÉ DE PRÉPARATION DE CHLORHYDRATE D'IVABRADINE SOLIDE
Publication
Application
Priority
- EP 15179744 A 20150804
- EP 2016068577 W 20160803
Abstract (en)
[origin: WO2017021466A1] The present invention relates to a process for the preparation of a solid form of ivabradine hydrochloride by reduction of Compound 2 or a salt thereof in an aqueous solvent followed by extraction of ivabradine wherein the extraction comprises the steps of: 1) adding a water immiscible solvent 2) separating the layers 3) washing the water immiscible solvent layer with an amount of an acidic aqueous solution sufficient to obtain a molar ratio ivabradine to acid between 1:0.001 and 1:0.2
IPC 8 full level
C07D 223/16 (2006.01); A61K 31/55 (2006.01)
CPC (source: EP)
C07D 223/16 (2013.01)
Citation (search report)
See references of WO 2017021466A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
EP 2016068577 W 20160803; EP 16745772 A 20160803