Global Patent Index - EP 3336192 A1

EP 3336192 A1 20180620 - RNA TRANSCRIPTION VECTOR AND USES THEREOF

Title (en)

RNA TRANSCRIPTION VECTOR AND USES THEREOF

Title (de)

RNA-TRANSKRIPTIONSVEKTOREN UND VERWENDUNG DAFÜR

Title (fr)

VECTEUR DE TRANSCRIPTION D'ARN ET SES UTILISATIONS

Publication

EP 3336192 A1 20180620 (EN)

Application

EP 18153133 A 20141112

Previously filed application

PCT/EP2014/074349 20141112 WO

Priority

  • EP 13192555 A 20131112
  • EP 14799996 A 20141112
  • EP 2014074349 W 20141112

Abstract (en)

The present invention in general relates to an improved RNA transcription vector, which is very suitable for the production of mRNA for in vivo therapeutic purposes. The improvements in the vector in particular reside in the presence of a transcription enhancer and a nuclear retention element.

IPC 8 full level

C12N 15/85 (2006.01); A61K 31/7088 (2006.01); A61K 39/00 (2006.01)

CPC (source: EA EP KR US)

A61K 31/7105 (2013.01 - EA EP KR US); A61K 39/0011 (2013.01 - EA EP KR US); A61K 48/0066 (2013.01 - EA KR US); A61P 1/16 (2018.01 - EA EP); A61P 31/04 (2018.01 - EA EP); A61P 31/10 (2018.01 - EA EP); A61P 31/12 (2018.01 - EA EP); A61P 31/18 (2018.01 - EA EP); A61P 35/00 (2018.01 - EA EP); A61P 37/08 (2018.01 - EA EP); C07K 14/70575 (2013.01 - EA KR US); C07K 14/70596 (2013.01 - EA KR US); C12N 15/85 (2013.01 - EA EP KR US); A61K 2039/53 (2013.01 - EA EP KR US); A61K 2039/54 (2013.01 - EA EP KR US); A61K 2039/55516 (2013.01 - EA EP KR US); C12N 2320/52 (2013.01 - EA EP KR US); C12N 2810/10 (2013.01 - EA KR US); C12N 2830/50 (2013.01 - EA EP KR US); C12N 2840/105 (2013.01 - EA EP KR US)

Citation (search report)

  • [AD] WO 2009034172 A1 20090319 - UNIV BRUXELLES [BE], et al
  • [Y] WO 2009075886 A1 20090618 - SCRIPPS RESEARCH INST [US], et al
  • [XY] US 2004043468 A1 20040304 - MAURO VINCENT P [US], et al
  • [Y] WO 0155369 A1 20010802 - SCRIPPS RESEARCH INST [US], et al
  • [YD] NICHOLAS K CONRAD ET AL: "A Kaposi's sarcoma virus RNA element that increases the nuclear abundance of intronless transcripts", THE EMBO JOURNAL, vol. 24, no. 10, 18 May 2005 (2005-05-18), pages 1831 - 1841, XP055111814, ISSN: 0261-4189, DOI: 10.1038/sj.emboj.7600662 & NICHOLAS K CONRAD ET AL: "Supplemental Information to: A Kaposi's sarcoma virus RNA element that increases the nuclear abundance of intronless transcripts", THE EMBO JOURNAL, vol. 24, no. 10, 18 May 2005 (2005-05-18), pages 1831 - 1841, XP002722819, ISSN: 0261-4189, Retrieved from the Internet <URL:http://emboj.embopress.org/content/embojnl/24/10/1831/DC1/embed/inline-supplementary-material-1.pdf?download=true> [retrieved on 20140403]
  • [Y] KAZIMIERZ T. TYCOWSKI ET AL: "Conservation of a Triple-Helix-Forming RNA Stability Element in Noncoding and Genomic RNAs of Diverse Viruses", CELL REPORTS, vol. 2, no. 1, 5 July 2012 (2012-07-05), pages 26 - 32, XP055111571, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2012.05.020 & KAZIMIERZ T TYCOWSKI, SHU MEI-DI, BORAH SUMIT, SHI MARY, STEITZ JOAN A.: "Supplemental Information to: Conservation of a Triple-Helix-Forming RNA Stability Element in Noncoding and Genomic RNAs of Diverse Viruses", 5 July 2012 (2012-07-05), XP002722820, Retrieved from the Internet <URL:http://www.sciencedirect.com/science/article/pii/S2211124712001593/pdfft?md5=cb6cc4b5af2540243b6346608a45bccb&pid=1-s2.0-S2211124712001593-main.pdf> [retrieved on 20140403]
  • [Y] J. M. PAWLICKI ET AL: "Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production", MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, vol. 63, no. 2, 7 July 2008 (2008-07-07), pages 405 - 76, XP055111700, ISSN: 1092-2172, DOI: 10.1128/JVI.02244-06
  • [Y] MARIA J. MASSIMELLI ET AL: "Stability of a Long Noncoding Viral RNA Depends on a 9-nt Core Element at the RNA 5' End to Interact with Viral ORF57 and Cellular PABPC1", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, vol. 7, no. 8, 16 October 2011 (2011-10-16), pages 1145 - 1160, XP055111577, ISSN: 1449-2288, DOI: 10.7150/ijbs.7.1145
  • [XY] JALECO A C ET AL: "Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 94, no. 8, 15 October 1999 (1999-10-15), pages 2637 - 2646, XP009133172, ISSN: 0006-4971
  • [Y] DATABASE Geneseq [online] 24 January 2008 (2008-01-24), "Gtx IRES DNA sequence PCR primer SEQ ID NO:31.", XP002722821, retrieved from EBI accession no. GSN:ANZ24567 Database accession no. ANZ24567 & JP 2007295846 A 20071115 - KANEKA CORP, et al
  • [Y] M. C.- Y. HU ET AL: "rRNA-complementarity in the 5' untranslated region of mRNA specifying the Gtx homeodomain protein: Evidence that base- pairing to 18S rRNA affects translational efficiency", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 96, no. 4, 16 February 1999 (1999-02-16), pages 1339 - 1344, XP055111718, ISSN: 0027-8424, DOI: 10.1073/pnas.96.4.1339

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2015071295 A1 20150521; AU 2014350222 A1 20160623; AU 2014350222 B2 20200227; BR 112016010595 A2 20171205; CA 2929203 A1 20150521; CA 2929203 C 20230418; CA 3191243 A1 20150521; CN 105849269 A 20160810; CN 105849269 B 20200717; CN 111621524 A 20200904; DK 3068888 T3 20180507; DK 3336192 T3 20220314; EA 035313 B1 20200527; EA 201690965 A1 20160930; EP 3068888 A1 20160921; EP 3068888 B1 20180131; EP 3336192 A1 20180620; EP 3336192 B1 20211208; ES 2666380 T3 20180504; ES 2908268 T3 20220428; HK 1226097 A1 20170922; HU E038831 T2 20181128; HU E058792 T2 20220928; IL 245596 A0 20160630; IL 245596 B 20191031; JP 2016537978 A 20161208; JP 2019146589 A 20190905; JP 6530393 B2 20190612; JP 6900054 B2 20210707; KR 102267412 B1 20210621; KR 102396589 B1 20220510; KR 20160090317 A 20160729; KR 20210076181 A 20210623; MX 2016006134 A 20170120; NO 3068888 T3 20180630; NZ 720885 A 20220225; PL 3068888 T3 20180731; PL 3336192 T3 20220404; PT 3068888 T 20180424; PT 3336192 T 20220310; SG 11201603482R A 20160530; US 10159755 B2 20181225; US 10864284 B2 20201215; US 2016279266 A1 20160929; US 2018353625 A1 20181213; US 2021060182 A1 20210304

DOCDB simple family (application)

EP 2014074349 W 20141112; AU 2014350222 A 20141112; BR 112016010595 A 20141112; CA 2929203 A 20141112; CA 3191243 A 20141112; CN 201480071159 A 20141112; CN 202010547507 A 20141112; DK 14799996 T 20141112; DK 18153133 T 20141112; EA 201690965 A 20141112; EP 14799996 A 20141112; EP 18153133 A 20141112; ES 14799996 T 20141112; ES 18153133 T 20141112; HK 16114308 A 20161215; HU E14799996 A 20141112; HU E18153133 A 20141112; IL 24559616 A 20160510; JP 2016530224 A 20141112; JP 2019092623 A 20190516; KR 20167015562 A 20141112; KR 20217018401 A 20141112; MX 2016006134 A 20141112; NO 14799996 A 20141112; NZ 72088514 A 20141112; PL 14799996 T 20141112; PL 18153133 T 20141112; PT 14799996 T 20141112; PT 18153133 T 20141112; SG 11201603482R A 20141112; US 201415034048 A 20141112; US 201816106912 A 20180821; US 202017097815 A 20201113