EP 3349768 A1 20180725 - ANTIBODIES FOR GENERATING ANTI-INFLAMMATORY MACROPHAGE AND RELATED USES
Title (en)
ANTIBODIES FOR GENERATING ANTI-INFLAMMATORY MACROPHAGE AND RELATED USES
Title (de)
ANTIKÖRPER ZUR ERZEUGUNG ANTIINFLAMMATORISCHER MAKROPHAGEN UND ENTSPRECHENDE VERWENDUNGEN
Title (fr)
ANTICORPS POUR LA PRODUCTION DE MACROPHAGES ANTI-INFLAMMATOIRES ET UTILISATIONS ASSOCIÉES
Publication
Application
Priority
- US 201562218785 P 20150915
- US 2016051290 W 20160912
Abstract (en)
[origin: WO2017048629A1] The invention provides specific anti-Cathepsin G antibodies that are capable of inducing formation of anti-inflammatory macrophage. The invention also provides methods for generating anti-inflammatory macrophages. The methods involve contacting bone marrow cells or monocytes with a Cathepsin G antibody described herein, and culturing the cell mixture under conditions to allow formation of M2 macrophage. Also provided in the invention are therapeutic methods of using a pharmaceutical composition containing a Cathepsin G antibody or induced M2 macrophage described herein for treating autoimmune diseases and other disorders associated with undesired immune responses.
IPC 8 full level
A61K 35/12 (2015.01); A61K 35/15 (2015.01); A61K 49/16 (2006.01); C12N 5/0786 (2010.01)
CPC (source: EP)
A61K 39/4614 (2023.05); A61K 39/4621 (2023.05); A61K 39/4622 (2023.05); A61K 39/46433 (2023.05); A61P 37/06 (2018.01); C07K 16/40 (2013.01); C12N 5/0645 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/622 (2013.01); C07K 2317/64 (2013.01); C07K 2317/70 (2013.01); C07K 2317/74 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2017048629 A1 20170323; AU 2016324021 A1 20180412; EP 3349768 A1 20180725; EP 3349768 A4 20190123
DOCDB simple family (application)
US 2016051290 W 20160912; AU 2016324021 A 20160912; EP 16847105 A 20160912