EP 3350318 B1 20220413 - METHODS RELATING TO ACTIVATED DENDRITIC CELL COMPOSITIONS FOR SUBJECTS WITH ADVANCED CANCERS
Title (en)
METHODS RELATING TO ACTIVATED DENDRITIC CELL COMPOSITIONS FOR SUBJECTS WITH ADVANCED CANCERS
Title (de)
VERFAHREN IM ZUSAMMENHANG MIT AKTIVIERTEN DENDRITISCHEN ZELLZUSAMMENSETZUNGEN FÜR PERSONEN MIT FORTGESCHRITTENEN KREBSERKRANKUNGEN
Title (fr)
PROCÉDÉS RELATIFS À DES COMPOSITIONS DE CELLULES DENDRITIQUES ACTIVÉES POUR DES SUJETS ATTEINTS DE CANCERS AVANCÉS
Publication
Application
Priority
- US 201562219058 P 20150915
- US 2016051781 W 20160914
Abstract (en)
[origin: WO2017048875A1] The present disclosure provides partially mature and activated dendritic cells that produce levels of cytokines/chemokines, for example, one or any combination of, and/or all of IL-6, IL-8, IL-12 and/or TNFα, that are correlated with improved clinical outcomes, significantly increased survival times and significantly increased times to tumor or cancer recurrence. The determined threshold amounts of these cytokines can be used for (i) a immunotherapeutic potency test for activated dendritic cells, (ii) selecting responder patients, (iii) rejecting non-responder patients, and (iv) to screen for dendritic cell activation or maturation agents that can also induce the production of the threshold amount of the cytokines/chemokines.
IPC 8 full level
C12N 5/0784 (2010.01); A61K 35/15 (2015.01); C07K 14/525 (2006.01); C07K 14/535 (2006.01); C07K 14/54 (2006.01); C07K 14/57 (2006.01); C12N 5/02 (2006.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); G01N 33/68 (2006.01)
CPC (source: CN EP IL KR RU US)
A61K 35/15 (2013.01 - IL US); A61K 39/4615 (2023.05 - CN EP KR RU); A61K 39/4622 (2023.05 - CN EP KR RU); A61K 39/4644 (2023.05 - CN EP KR RU); A61P 35/00 (2018.01 - EP IL US); C07K 14/525 (2013.01 - EP IL RU US); C07K 14/5412 (2013.01 - EP IL RU US); C07K 14/5421 (2013.01 - EP IL RU US); C07K 14/5434 (2013.01 - EP IL RU US); C12N 5/0639 (2013.01 - CN EP IL KR RU US); G01N 33/5023 (2013.01 - CN EP IL RU US); G01N 33/5047 (2013.01 - CN EP IL KR RU US); G01N 33/56972 (2013.01 - CN EP IL US); G01N 33/6863 (2013.01 - IL KR); G01N 33/6869 (2013.01 - CN EP IL KR US); A61K 2239/31 (2023.05 - CN EP KR RU); A61K 2239/38 (2023.05 - CN EP KR RU); C12N 2500/72 (2013.01 - CN EP IL KR US); C12N 2501/22 (2013.01 - CN EP IL KR US); C12N 2501/2304 (2013.01 - CN IL KR); C12N 2501/2307 (2013.01 - CN IL KR); C12N 2501/2313 (2013.01 - CN IL KR); C12N 2501/2315 (2013.01 - CN IL KR); G01N 2333/5255 (2013.01 - EP IL US); G01N 2333/5412 (2013.01 - CN EP IL US); G01N 2333/5421 (2013.01 - CN EP IL US); G01N 2333/5434 (2013.01 - CN EP IL US); G01N 2800/52 (2013.01 - CN EP IL US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017048875 A1 20170323; AU 2016323066 A1 20180510; AU 2016323066 B2 20230427; AU 2023208190 A1 20230817; BR 112018005180 A2 20181002; BR 112018005180 B1 20231128; CA 2998614 A1 20170323; CN 108291204 A 20180717; CN 116413420 A 20230711; DK 3350318 T3 20220711; EP 3350318 A1 20180725; EP 3350318 A4 20191113; EP 3350318 B1 20220413; EP 3971285 A2 20220323; EP 3971285 A3 20220622; ES 2923769 T3 20220930; HK 1258885 A1 20191122; HU E059560 T2 20221128; IL 258071 A 20180531; IL 258071 B 20210930; IL 286225 A 20211031; IL 286225 B1 20240701; JP 2018537949 A 20181227; JP 2022028818 A 20220216; JP 2024019229 A 20240208; JP 6980650 B2 20211215; KR 20180044430 A 20180502; MX 2018003197 A 20180926; MX 2022008806 A 20220811; PL 3350318 T3 20220816; RU 2018113435 A 20191016; RU 2018113435 A3 20200325; RU 2749610 C2 20210616; US 2019046568 A1 20190214
DOCDB simple family (application)
US 2016051781 W 20160914; AU 2016323066 A 20160914; AU 2023208190 A 20230727; BR 112018005180 A 20160914; CA 2998614 A 20160914; CN 201680066721 A 20160914; CN 202211533672 A 20160914; DK 16847253 T 20160914; EP 16847253 A 20160914; EP 21189488 A 20160914; ES 16847253 T 20160914; HK 19101358 A 20190125; HU E16847253 A 20160914; IL 25807118 A 20180313; IL 28622521 A 20210909; JP 2018513634 A 20160914; JP 2021186960 A 20211117; JP 2023200819 A 20231128; KR 20187010610 A 20160914; MX 2018003197 A 20160914; MX 2022008806 A 20180314; PL 16847253 T 20160914; RU 2018113435 A 20160914; US 201615759699 A 20160914