EP 3360549 A1 20180815 - SMALL MOLECULE THERAPEUTICS FOR TREATING METACHROMATIC LEUKODYSTROPHY
Title (en)
SMALL MOLECULE THERAPEUTICS FOR TREATING METACHROMATIC LEUKODYSTROPHY
Title (de)
KLEINMOLEKÜLIGE THERAPEUTIKA ZUR BEHANDLUNG VON METACHROMATISCHER LEUKODYSTROPHIE
Title (fr)
THÉRAPEUTIQUES PAR PETITES MOLÉCULES POUR LE TRAITEMENT DE LA LEUCODYSTROPHIE MÉTACHROMATIQUE
Publication
Application
Priority
EP 17156089 A 20170214
Abstract (en)
The present invention pertains to a novel treatment of pathologies caused by an increased synthesis or accumulation of sulfolipids such as sulfatide. The invention provides compounds isolated from Epicoccum nigrum strains 749 and 800, which were identified as inhibitors of Sulfotransferase, an enzyme catalyzing the generation of sulfatide. Sulfatides accumulate in the central nervous system (CNS) and lead to a degeneration of white matter. The present invention therefore preferably provides new therapeutic options for treating such diseases by administration of Epicoccum nigrum derived compounds. Further provided are pharmaceutical compositions comprising these compounds.
IPC 8 full level
A61K 31/34 (2006.01); A61K 31/7042 (2006.01); A61P 25/28 (2006.01)
CPC (source: EP)
A61K 31/34 (2013.01); A61K 31/7042 (2013.01); A61P 25/28 (2017.12)
Citation (applicant)
- US 2012108526 A1 20120503 - VAN GINKEL ROEL [NZ], et al
- WO 2011071396 A1 20110616 - VILLAS-BOAS SILAS GRANATO [NZ], et al
- WO 2005047275 A1 20050526 - AVENTIS PHARMA GMBH [DE], et al
- US 6306365 B1 20011023 - RUOSLAHTI ERKKI [US], et al
- BIFFI A ET AL., J CLIN INVEST., vol. 113, no. 8, April 2004 (2004-04-01), pages 1118 - 29
- SUNDARAM KS; LEV M, J LIPID RES., vol. 29, no. 11, November 1988 (1988-11-01), pages 1475 - 9
- ABULROB ET AL., J. NEUROCHEM, vol. 95, 2005, pages 1201 - 1214
- PARDRIDGE ET AL., PHARMACOL. RES, vol. 12, 1995, pages 807 - 816
- XIA ET AL., J. VIROL., vol. 74, 2000, pages 11359 - 11366
- PARDRIDGE ET AL., J. PHARMACOL. EXP. THER., vol. 259, 1991, pages 66 - 70
- GAILLARD ET AL., INTERNATIONAL CONGRESS SERIES, vol. 1277, 2005, pages 185 - 198
Citation (search report)
- [X] EP 1541580 A1 20050615 - SEIKAGAKU KOGYO CO LTD [JP]
- [I] WO 2008012555 A2 20080131 - ISIS INNOVATION [GB], et al
- [AD] WO 2005047275 A1 20050526 - AVENTIS PHARMA GMBH [DE], et al
- [AD] US 2012108526 A1 20120503 - VAN GINKEL ROEL [NZ], et al
- [I] LI W ET AL: "A capillary electrophoresis method with dynamic pH junction stacking for the monitoring of cerebroside sulfotransferase", JOURNAL OF CHROMATOGRAPHY A 20150814 ELSEVIER NLD, vol. 1407, 14 August 2015 (2015-08-14), pages 222 - 227, XP002770903, DOI: 10.1016/J.CHROMA.2015.06.053
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
EP 17156089 A 20170214; EP 2018053652 W 20180214