Global Patent Index - EP 3388530 A1

EP 3388530 A1 20181017 - NUCLEIC ACID MODIFICATION AND IDENTIFICATION METHOD

Title (en)

NUCLEIC ACID MODIFICATION AND IDENTIFICATION METHOD

Title (de)

VERFAHREN ZUR MODIFIZIERUNG UND IDENTIFIZIERUNG VON NUKLEINSÄUREN

Title (fr)

MODIFICATION ET PROCÉDÉ D'IDENTIFICATION D'ACIDE NUCLÉIQUE

Publication

EP 3388530 A1 20181017 (EN)

Application

EP 17166629 A 20170413

Priority

EP 17166629 A 20170413

Abstract (en)

The invention provides a method of identifying a polynucleic acid (PNA) comprising the steps of providing a PNA; modifying one or more nucleobases of the PNA by addition or removal of a hydrogen bonding partner, thereby altering the base pairing capacity of the one or more nucleobases; base pairing a complementary nucleic acid to the PNA, including base pairing to at least one modified nucleobase; identifying the sequence of the complementary nucleic acid at least at the position that is complementary to at least one modified nucleobase.

IPC 8 full level

C12Q 1/68 (2018.01)

CPC (source: EP)

C12Q 1/6869 (2013.01)

Citation (applicant)

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Citation (search report)

  • [A] ERIN E. DUFFY ET AL: "Tracking Distinct RNA Populations Using Efficient and Reversible Covalent Chemistry", MOLECULAR CELL., vol. 59, no. 5, 1 September 2015 (2015-09-01), US, pages 858 - 866, XP055410849, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2015.07.023
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  • [X] STEPHEN M. TESTA ET AL: "Thermodynamics of RNA-RNA Duplexes with 2- or 4-Thiouridines: Implications for Antisense Design and Targeting a Group I Intron +", BIOCHEMISTRY, vol. 38, no. 50, 1 December 1999 (1999-12-01), US, pages 16655 - 16662, XP055411109, ISSN: 0006-2960, DOI: 10.1021/bi991187d
  • [X] HARA H ET AL: "4thiouridine-specific spin-labeling of E. coli transfer RNA", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 38, no. 2, 23 January 1970 (1970-01-23), pages 305 - 311, XP024776827, ISSN: 0006-291X, [retrieved on 19700123], DOI: 10.1016/0006-291X(70)90713-8
  • [A] GILAD FUCHS ET AL: "4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells", GENOME BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 15, no. 5, 9 May 2014 (2014-05-09), pages R69, XP021188922, ISSN: 1465-6906, DOI: 10.1186/GB-2014-15-5-R69

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3388530 A1 20181017

DOCDB simple family (application)

EP 17166629 A 20170413