EP 3394616 B1 20190424 - A METHOD AND A SYSTEM FOR DETERMINATIONS OF CELL SUSPENSIONS
Title (en)
A METHOD AND A SYSTEM FOR DETERMINATIONS OF CELL SUSPENSIONS
Title (de)
VERFAHREN UND SYSTEM ZUR BESTIMMUNG VON ZELLSUSPENSIONEN
Title (fr)
PROCÉDÉ ET SYSTÈME DE DÉTERMINATIONS DE SUSPENSIONS DE CELLULES
Publication
Application
Priority
- EP 15202725 A 20151224
- EP 2016082372 W 20161222
Abstract (en)
[origin: WO2017109068A1] The invention relates to a method of determining a concentration of a substance in a cell suspension, said method comprising the following steps: - determining the concentration of the substance by: - using the results of absorption measurements performed at n local sample volumes contained at different average chamber heights of a chamber arrangement comprising the cell suspension and local substance concentration in said respective local sample volumes determined based on said respective absorption measurements; - using a substance concentration model comprising local substance concentration as a function of chamber height, and - determining the substance concentration as the infinite chamber height substance concentration using said substance concentration model and the determined local substance concentrations, wherein n is at least 2, such as at least 3, such as at least 4, wherein, optionally, the cell suspension is whole blood and the substance is Hb and wherein the method further comprises determining cRBC based on the determined Hb concentration and a determined Mean Corpuscular Hemoglobin (MCH). The invention also relates to a system for executing the method.
IPC 8 full level
G01N 33/49 (2006.01); B01L 3/00 (2006.01); G01N 21/59 (2006.01)
CPC (source: EP US)
B01L 3/502707 (2013.01 - EP US); G01N 21/0303 (2013.01 - EP US); G01N 33/49 (2013.01 - EP US); G01N 33/721 (2013.01 - US); B01L 2200/148 (2013.01 - EP US); B01L 2300/0816 (2013.01 - EP US); B01L 2400/0406 (2013.01 - EP US); G01N 2021/0378 (2013.01 - EP US); G01N 2021/0392 (2013.01 - EP US); G01N 2201/066 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017109068 A1 20170629; CN 108431600 A 20180821; EP 3394616 A1 20181031; EP 3394616 B1 20190424; JP 2019506600 A 20190307; JP 6518016 B2 20190522; TR 201909510 T4 20190722; US 10782306 B2 20200922; US 2018372758 A1 20181227
DOCDB simple family (application)
EP 2016082372 W 20161222; CN 201680075832 A 20161222; EP 16825752 A 20161222; JP 2018533248 A 20161222; TR 201909510 T 20161222; US 201616064780 A 20161222