EP 3395328 A1 20181031 - COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF PROSTAGLANDINS TO SUBCUTANEOUS FAT

Title (en)

COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF PROSTAGLANDINS TO SUBCUTANEOUS FAT

Title (de)

ZUSAMMENSETZUNGEN UND VERFAHREN ZUR TOPISCHEN VERABREICHUNG VON PROSTAGLANDINEN IN SUBKUTANES FETT

Title (fr)

COMPOSITIONS ET MÉTHODES POUR L'ADMINISTRATION TOPIQUE DE PROSTAGLANDINES DANS LA GRAISSE SOUS-CUTANÉE

Publication

EP 3395328 A1 20181031 (EN)

Application

EP 18162319 A 20140509

Priority

US 201361822139 P 20130510
EP 16177742 A 20140509
EP 14729803 A 20140509
US 2014037512 W 20140509

Abstract (en)

Described herein are compositions comprising a prostaglandin FP receptor agonist (PFPRA) compound and a fatty acid ester ( e . g ., isopropyl myristate), optionally comprising an ointment base such as a hydrocarbon base ( e . g ., petroleum jelly) and/or an organic alcohol ( e . g ., propylene glycol), that, when topically applied to the skin, locally delivers a therapeutically effective amount of the PFPRA compound to subcutaneous fat under the skin, and methods of preparation. The therapeutic effect is, for example, reduction of the subcutaneous fat under the skin. Further provided are methods of reducing body fat in a subject comprising topically administering the composition to the subject.

IPC 8 full level

A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/23 (2006.01); A61K 31/5575 (2006.01); A61K 47/06 (2006.01); A61K 47/14 (2017.01); A61K 47/10 (2017.01)

CPC (source: EP IL KR RU US)

A61K 9/0014 (2013.01 - EP IL KR US); A61K 9/06 (2013.01 - EP IL KR RU US); A61K 31/23 (2013.01 - EP IL KR US); A61K 31/5575 (2013.01 - EP IL KR RU US); A61K 47/06 (2013.01 - EP IL KR US); A61K 47/10 (2013.01 - EP IL US); A61K 47/14 (2013.01 - EP IL KR RU US); A61K 47/44 (2013.01 - IL KR RU); A61P 3/00 (2018.01 - EP IL); A61P 3/04 (2018.01 - EP IL); A61P 27/02 (2018.01 - EP IL); A61P 43/00 (2018.01 - EP IL)

C-Set (source: EP US)

Citation (applicant)

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Citation (search report)

[XI] US 2013023536 A1 20130124 - GRAHAM RICHARD S [US], et al
[XYI] US 2012129789 A1 20120524 - YOELIN STEVEN [US]
[XY] EP 2228058 A1 20100915 - NOVAGALI PHARMA SA [FR]
[X] US 2012251613 A1 20121004 - JAIN RAJEEV [IN], et al
[Y] HEE YOUNG CHOI ET AL: "In Vitro Study of Antiadipogenic Profile of Latanoprost, Travoprost, Bimatoprost, and Tafluprost in Human Orbital Preadiopocytes", JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS., vol. 28, no. 2, April 2012 (2012-04-01), US, pages 146 - 152, XP055131156, ISSN: 1080-7683, DOI: 10.1089/jop.2011.0160

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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