EP 3398959 B1 20201125 - METHOD FOR PREPARING LIXISENATIDE
Title (en)
METHOD FOR PREPARING LIXISENATIDE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON LIXISENATID
Title (fr)
MÉTHODE DE PRÉPARATION DU LIXISÉNATIDE
Publication
Application
Priority
- CN 201511032042 A 20151231
- CN 2016110374 W 20161216
Abstract (en)
[origin: EP3398959A1] A method for preparing Lixisenatide. According to a peptide sequence structure of Lixisenatide peptide, specially protected serine dipeptide is used as a raw material and coupled into a peptide sequence. Because of a ring-shaped structure similar to that of proline is formed, the rotation of a peptide bond can be effectively prevented, the contraction of a peptide chain curling agent is suppressed, so that active functional groups are fully exposed, thereby facilitating the coupling of the amino acid, and reducing the occurrence of defects and other side effects.
IPC 8 full level
C07K 14/605 (2006.01); C07K 1/06 (2006.01)
CPC (source: CN EP US)
C07K 1/062 (2013.01 - US); C07K 1/10 (2013.01 - US); C07K 1/20 (2013.01 - US); C07K 14/57563 (2013.01 - CN US); C07K 14/605 (2013.01 - EP); C07K 1/061 (2013.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 3398959 A1 20181107; EP 3398959 A4 20190814; EP 3398959 B1 20201125; CN 106928340 A 20170707; US 2020277328 A1 20200903; WO 2017114192 A1 20170706
DOCDB simple family (application)
EP 16880982 A 20161216; CN 201511032042 A 20151231; CN 2016110374 W 20161216; US 201616067067 A 20161216