EP 3400232 A4 20191016 - AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS
Title (en)
AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS
Title (de)
AMINOGLYKOSIDDERIVATE UND VERWENDUNGEN DAVON ZUR BEHANDLUNG GENETISCHER ERKRANKUNGEN
Title (fr)
DÉRIVÉS D'AMINOGLYCOSIDES ET LEURS UTILISATIONS POUR TRAITER LES MALADIES GÉNÉTIQUES
Publication
Application
Priority
- US 201662274915 P 20160105
- IL 2016050969 W 20160902
Abstract (en)
[origin: WO2017118968A1] Novel aminoglycosides, represented by Formulae (I), (Ia), (III) and (IIIa), as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
IPC 8 full level
C07H 15/23 (2006.01); A61K 31/7036 (2006.01); A61P 7/04 (2006.01); A61P 21/00 (2006.01); A61P 21/04 (2006.01); C07H 15/222 (2006.01); C07H 15/224 (2006.01)
CPC (source: EP US)
A61P 7/04 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 21/04 (2017.12 - EP); C07H 15/224 (2013.01 - EP US); C07H 15/23 (2013.01 - EP US)
Citation (search report)
- [I] WO 2007113841 A2 20071011 - TECHNION RES & DEV FOUNDATION [IL], et al
- [I] KR 20150137577 A 20151209 - UNIV SOGANG IND UNIV COOP FOUN [KR]
- [X] JUAN PABLO MAIANTI ET AL: "Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes", MEDCHEMCOMM, vol. 7, no. 1, 1 January 2016 (2016-01-01), United Kingdom, pages 170 - 176, XP055611592, ISSN: 2040-2503, DOI: 10.1039/C5MD00429B
- [X] D H DAVIES ET AL: "Semisynthetic aminoglycoside antibacterials. 6. Synthesis of sisomicin, antibiotic G-52, and novel 6'-substituted analogs of sisomicin from aminoglycoside 66-40C", JOURNAL OF MEDICINAL CHEMISTRY, 1 February 1978 (1978-02-01), United States, pages 189 - 193, XP055611609, Retrieved from the Internet <URL:https://pubs.acs.org/doi/pdf/10.1021/jm00200a009?rand=1jc88k36> DOI: 10.1021/jm00200a009
- See references of WO 2017118968A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017118968 A1 20170713; EP 3400232 A1 20181114; EP 3400232 A4 20191016; US 2019016746 A1 20190117
DOCDB simple family (application)
IL 2016050969 W 20160902; EP 16883508 A 20160902; US 201616068165 A 20160902