EP 3400242 A1 20181114 - REDUCTION OF HIGH MOLECULAR WEIGHT SPECIES, ACIDIC CHARGE SPECIES, AND FRAGMENTS IN A MONOCLONAL ANTIBODY COMPOSITION
Title (en)
REDUCTION OF HIGH MOLECULAR WEIGHT SPECIES, ACIDIC CHARGE SPECIES, AND FRAGMENTS IN A MONOCLONAL ANTIBODY COMPOSITION
Title (de)
REDUKTION VON SPEZIES MIT HOHEM MOLEKULARGEWICHT, SAUER GELADENEN SPEZIES UND FRAGMENTEN IN EINER MONOKLONALEN ANTIKÖRPERZUSAMMENSETZUNG
Title (fr)
RÉDUCTION DES ESPÈCES DE MASSE MOLÉCULAIRE ÉLEVÉE, DES ESPÈCES DE CHARGE ACIDE, ET DES FRAGMENTS DANS UNE COMPOSITION D'ANTICORPS MONOCLONAUX
Publication
Application
Priority
- US 201662275386 P 20160106
- US 2017012362 W 20170105
Abstract (en)
[origin: WO2017120359A1] Alterations in bioreactor cell culture feeding to an extended or continuous feed following an initial period of no feeding reduces the level of high molecular weight, acid charge, and fragment species of monoclonal antibodies expressed in the culture, and enhances the level of afucosylated species of monoclonal antibodies expressed in the culture. Regular fucose infusions following an initial period of no feed media infusion reduces the level of afucosylated species of monoclonal antibodies expressed in the culture. Cell culture manipulation may be used to modulate the level of species of monoclonal antibodies.
IPC 8 full level
C07K 16/24 (2006.01)
CPC (source: EP US)
C07K 16/241 (2013.01 - EP US); C12N 5/0682 (2013.01 - US); C07K 2317/14 (2013.01 - EP US); C07K 2317/41 (2013.01 - EP US); C12M 21/00 (2013.01 - US)
Citation (search report)
See references of WO 2017120359A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2017120359 A1 20170713; AU 2017206012 A1 20180726; CA 3010600 A1 20170713; CN 109153717 A 20190104; EP 3400242 A1 20181114; JP 2019500878 A 20190117; MX 2018008448 A 20190530; US 2019048070 A1 20190214
DOCDB simple family (application)
US 2017012362 W 20170105; AU 2017206012 A 20170105; CA 3010600 A 20170105; CN 201780015405 A 20170105; EP 17702445 A 20170105; JP 2018535148 A 20170105; MX 2018008448 A 20170105; US 201716067194 A 20170105