EP 3405475 B1 20220928 - SYNTHETIC OPIOID VACCINE
Title (en)
SYNTHETIC OPIOID VACCINE
Title (de)
SYNTHETISCHER OPIOIDIMPFSTOFF
Title (fr)
VACCIN CONTRE LES OPIOÏDES DE SYNTHÈSE
Publication
Application
Priority
- US 201662281262 P 20160121
- US 2017013865 W 20170118
Abstract (en)
[origin: WO2017127390A1] Fentanyl is an addictive prescription opioid that is over 80 times mora potent than morphine. The synthetic nature of fentanyl has enabled the creation of dangerous "designer drug' analogues that escape toxicology screening, yet display comparable potency to the parent drug. Alarmingly, a large number of fatalities have been linked to overdose of fentanyl derivatives. Herein, we report an effective immunotherapy for reducing the psychoactive effects of fentanyl class drugs. A single conjugate vaccine was created that elicited high levels of antibodies with cross-reactivity for a wide panel of fentanyl analogues, Moreover, vaccinated mice gained significant protection from lethal fentanyl doses. Lastly, a surface plasmon resonance (SPR)-based technique was established enabling drug specificity profiling of antibodies derived directly from serum. Our newiy developed fentanyl vaccine and analytical methods may assist in the battle against synthetic opioid abuse.
IPC 8 full level
A61K 39/00 (2006.01); A61K 39/385 (2006.01); A61K 47/68 (2017.01); A61P 25/30 (2006.01); A61P 37/04 (2006.01); C07K 1/00 (2006.01); C07K 16/44 (2006.01)
CPC (source: EP US)
A61K 39/0013 (2013.01 - EP US); A61K 39/385 (2013.01 - EP US); A61K 39/395 (2013.01 - US); A61K 47/643 (2017.07 - US); A61K 47/6829 (2017.07 - EP US); A61P 25/30 (2017.12 - EP US); A61P 37/04 (2017.12 - EP); C07K 1/00 (2013.01 - EP); C07K 16/44 (2013.01 - EP); A61K 2039/55505 (2013.01 - EP); A61K 2039/55561 (2013.01 - EP); C07K 2317/92 (2013.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017127390 A1 20170727; BR 112018014908 A2 20181218; CA 3015336 A1 20170727; CN 108884127 A 20181123; EP 3405475 A1 20181128; EP 3405475 A4 20190828; EP 3405475 B1 20220928; JP 2019506390 A 20190307; RU 2018130106 A 20200221; RU 2018130106 A3 20200526; US 11305010 B2 20220419; US 2021128720 A1 20210506
DOCDB simple family (application)
US 2017013865 W 20170118; BR 112018014908 A 20170118; CA 3015336 A 20170118; CN 201780007832 A 20170118; EP 17741829 A 20170118; JP 2018537799 A 20170118; RU 2018130106 A 20170118; US 201716071199 A 20170118