EP 3408217 B1 20201223 - MULTI-STAGE TARGET CELL ENRICHMENT USING A MICROFLUIDIC DEVICE
Title (en)
MULTI-STAGE TARGET CELL ENRICHMENT USING A MICROFLUIDIC DEVICE
Title (de)
MEHRSTUFIGE ZIELZELLENANREICHERUNG MIT EINER MIKROFLUIDISCHEN VORRICHTUNG
Title (fr)
ENRICHISSEMENT EN CELLULES CIBLES EN PLUSIEURS ÉTAGES UTILISANT UN DISPOSITIF MICROFLUIDIQUE
Publication
Application
Priority
SG 2016050040 W 20160128
Abstract (en)
[origin: WO2017131580A1] A microfluidic device comprises at least one inlet for receiving a sample comprising target cells and non-target cells; a first spiral channel portion having an upstream end in a central region and a downstream end in a peripheral region, the upstream end being coupled to the inlet, the first spiral channel portion being configured such that the target cells and the non- target cells occupy different streams at the downstream end; a first waste outlet arranged to couple with streams of non-target cells at the downstream end of the first spiral channel portion; a link channel portion arranged to couple with streams of target cells at the downstream end of the first spiral channel portion; a second spiral channel portion having an upstream end in a peripheral region and a downstream end in a central region, the upstream end of the second channel portion being coupled to the link channel portion, the second spiral channel portion being configured such that the target cells and the non-target cells occupy different streams at the downstream end; a second waste outlet arranged to couple with streams of non-target cells at the downstream end of the second spiral channel portion; and a sample outlet arranged to couple with streams of target cells at the downstream end of the second spiral channel portion.
IPC 8 full level
B81B 1/00 (2006.01); B01L 3/00 (2006.01); B07C 5/12 (2006.01)
CPC (source: EP US)
B01D 21/26 (2013.01 - EP); B01L 3/00 (2013.01 - EP); B01L 3/502761 (2013.01 - EP US); B07C 5/12 (2013.01 - EP); G01N 1/28 (2013.01 - EP); G01N 15/1023 (2024.01 - US); B01L 2200/0652 (2013.01 - EP US); B01L 2300/0816 (2013.01 - EP US); B01L 2300/0864 (2013.01 - EP); B01L 2300/088 (2013.01 - EP US); B01L 2300/0883 (2013.01 - EP US); G01N 2015/1028 (2024.01 - US); G01N 2015/1029 (2024.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017131580 A1 20170803; AU 2016389767 A1 20180712; AU 2016389767 B2 20190801; CN 108495809 A 20180904; CN 108495809 B 20230425; EP 3408217 A1 20181205; EP 3408217 A4 20191002; EP 3408217 B1 20201223; JP 2019509016 A 20190404; JP 6845246 B2 20210317; SG 11201805697W A 20180830; US 10898898 B2 20210126; US 2019344273 A1 20191114; US 2021101151 A1 20210408
DOCDB simple family (application)
SG 2016050040 W 20160128; AU 2016389767 A 20160128; CN 201680079601 A 20160128; EP 16888339 A 20160128; JP 2018533164 A 20160128; SG 11201805697W A 20160128; US 201616071146 A 20160128; US 202017126317 A 20201218